مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
The effect of lithium and exercise on the spatial learning and memory in the Wistar rats: the role of BDNF protein
The effect of lithium and exercise on the spatial learning and memory in the Wistar rats: the role of BDNF protein
Mohadeseh Chahkandi,1,*elham shoghi,2
1. Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran 2. Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
Introduction: Lithium has been found to have neuroprotective properties and can improve memory and learning in preclinical models of aging, traumatic brain injury, drug addiction, glutamate neurotoxicity, and Alzheimer's disease. Regular physical exercise (EX) is considered to be the most powerful non-pharmacological approach for promoting optimal brain health. Given the findings of previous research, it is hypothesized that moderate-intensity exercise and lithium treatments could promote improvements in spatial learning and memory in Wistar rats by activating brain-derived neurotrophic factor (BDNF) in the hippocampus. This study evaluated the role of BDNF in the effects of lithium and exercise on spatial learning and memory.
Methods: In this research, 28 male Wistar rats were divided into 4 groups; I: Control (Crt), animals did not receive drug; II: Li10 (10 mg/kg/day/ip); III: Moderate-intensity training (MIT); IV: Li10 and MIT (Li10+ MIT); One hour after the last injection, the Morris water maze (MWM) test was conducted. Moreover, the density of BDNF (brain-derived neurotrophic factor) was assessed by the ELIZA method.
Results: Our result showed the beneficial effects of exercise on spatial learning and memory; however, lithium administration alone cannot affect this. Additionally, exercise-exposed and lithium administration combined rats showed improvement in spatial learning and memory. Finally, we observed a positive role of BDNF protein in the exercise and lithium effects.
Conclusion: lithium or MIT separately affected the expression of the mitochondrial gene positively, however, combined lithium and MIT showed different effects. The BDNF protein has a positive role in the exercise and lithium effects.