• Application of Triboelectric Nanogenerators in Regenerative Medicine
  • Farniya Mohammadifar,1,* Fatemeh Moradbeygi,2 Arash Goodarzi,3 Zahra Abpeikar,4 Mohsen Safaei,5 Ahmad Reza Farmani,6
    1. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    2. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
    3. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    4. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    5. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    6. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran


  • Introduction: Regenerative medicine has created many hopes for the treatment of many organ defects and diseases. On the other hand, the role of electrical stimulation in improving the function of stem cells in regenerative medicine has been well proven. Therefore, the increasing need to provide electrical energy without the common challenges related to batteries such as heat generation and cell destruction has led to the expansion of research towards the use of nanogenerators in modern medical applications and especially in regeneration.
  • Methods: In this review, PubMed, ISI Web of Science, Google scholar and SCOPUS databases were searched for studies published up to September 2023 related to “Application of Triboelectric Nanogenerators in Regenerative Medicine” were addressed.
  • Results: The review of studies showed that triboelectric nanogenerators with electrical energy supply from mechanical movements and advantages such as lightness, flexibility, as well as reduced toxicity and no need for re-surgery can be considered as one of the most important advantages of using triboelectric nanogenerators in regenerative medicine. Also, the examination of the results showed that the electrical stimulation from the nanogenerator can help in wound healing, bone and nerve regeneration.
  • Conclusion: The use of nanogenerators in preparing scaffolds can create new horizons in tissue engineering and regenerative medicine.
  • Keywords: Electrical Stimulation, Triboelectric, Nanogenerators, Regenerative Medicine.