• Liposome-Loaded Hydrogels: Promising Biomaterials for Regenerative Medicine and Cancer Treatment
  • Farniya Mohammadifar,1,* Mahtab Tirgar,2 Arash Goodarzi,3 Zahra Abpeikar,4 Mohsen Safaei,5 Ahmad Reza Farmani,6
    1. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    2. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    3. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    4. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
    5. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran.
    6. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran


  • Introduction: Liposomes are known as small artificial vesicles that can be prepared from cholesterol and natural non-toxic phospholipids. Regarding, their advantages including hydrophobic and hydrophilic character (besides biocompatibility), liposomes are well known in nanomedicine and considered as a promising option for drug delivery. Considering the very important role of drug delivery in tissue engineering and the undeniable role of sustained drug release in cancer treatment, liposomes have found many applications in tissue engineering and cancer treatment. On the other hand, considering the advantages of hydrogels such as biocompatibility, sustained release and structural diversity, hydrogels loaded with liposomes seem to be a suitable option for use in tissue engineering and cancer treatment.
  • Methods: In this review, PubMed, ISI Web of Science, Google scholar and SCOPUS databases were searched for studies published up to September 2023 related to “Liposome-Loaded Hydrogels: Promising Biomaterials for Regenerative Medicine and Cancer Treatment” were addressed.
  • Results: Studies demonstrated that liposome-loaded hydrogels have very promising results in wound healing, bone regeneration, targeted release of cancer drugs, and even improved immunotherapy. Most of these results are due to the reduction of toxicity caused by the local and targeted release of the drug, as well as the cell adhesion and biocompatibility of the hydrogel.
  • Conclusion: The use of liposome-containing hydrogels can provide smart systems for targeted cancer treatment and tissue regeneration.
  • Keywords: Liposomes, Hydrogels, Drug Delivery, Regenerative Medicine, Cancer Treatment.