مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
Application of nanobiomaterials to improve angiogenesis in tissue engineering
Application of nanobiomaterials to improve angiogenesis in tissue engineering
Fariba Noori,1,*Mohsen Safaei,2Zahra Abpeikar,3Hamid Reza Ghaderi Jafarbeigloo,4Ahmad Reza Farmani,5Arash Goodarzi,6
1. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran 2. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran 3. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran 4. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran 5. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran 6. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
Introduction: Angiogenesis, a crucial step in the wound healing process, provides sufficient oxygen and nutrients to the wound site. The use of nanostructures has become an effective way to regulate the biological functions of cells. Biological nanomaterials have attracted a lot of attention in biomedical applications due to their unique structure and photoelectric and catalytic properties. Nanobiomaterials, such as nanoparticles and nanofibers, can be engineered to release growth factors or other bioactive molecules that promote angiogenesis. Nanomaterials not only act as carriers that effectively deliver factors such as angiogenesis-related proteins and mRNA, but also mimic the nanotopological structure of the primary ECM of blood vessels and stimulate gene expression of angiogenic effects that facilitate angiogenesis.
Methods: A document search was conducted on the Scopus database, Google Scholar and PubMed database of studies published from January 2015 to September 2023 with English keywords, including gene editing, nanobiomaterials, angiogenesis and tissue engineering. A combined Hunt of keywords was done using Boolean drivers AND and OR. Data analysis was done qualitatively.
Results: Among the nanomaterials with angiogenic properties include: Gold, Cu2S, HA, TCP, Bioactive glass nanoparticle/nanofiber, Zinc oxide nanoflowers/ nanoparticles, Terbium hydroxide rods/ spheres, Neodymium, TiO2 ,are effective in regenerating hard and soft tissues (mainly bone and skin, respectively). It is possible to increase the efficiency of nanofibrous scaffolds in order to improve tissue repair and regeneration in different ways, such as: simultaneous delivery of angiogenic growth factors such as: PDGF, (TGF-β), angiogenin and other bioactive molecules (bioactive glass), use of small angiogenic molecules such as angiogenin and phytochemicals (such as curcumin), surface functionalization of nanofibrous scaffolds with angiogenic bioactive molecules, addition of inorganic elements (such as cerium and europium), highly controlled doping of angiogenic elements to the structure of bioceramics (eg, calcium phosphate and glass bioactives), implantation of various somatic and stem cells such as endothelial cells (ECs) and mesenchymal stem cells (MSCs). In general, the use of some natural and synthetic polymers that have inherent angiogenic properties for example, hyaluronic acid, collagen, elastin, PLA, PCL, PLCL, hyaluronic acid and their composites leads to an increase in the expression of angiogenic growth factors and cytokines, including VEGF -D, matrix metalloproteinase-2 (MMP2), matrix metalloproteinase-3 (MMP3) and matrix metalloproteinase 19 (MMP19).
Conclusion: Therefore, the electrospun nanofibers benefit from the high loading efficiency of therapeutic agents due to the high surface area to volume ratio compared to other conventional nanoscale delivery vehicles such as liposomes, polymeric micelles, and complexes. In addition, the tunable properties of the polymer matrix (eg, porosity, diameter, and morphology) allow the incorporation of various drugs into the electrospun scaffolds, thus leading to effective local delivery of drugs to the target tissue.