• hematological research during pregnancy
  • Golnaz Minaeian,1 Saman Hakimian,2,*
    1. Masters student in hematology,Shiraz University of Medical Sciences
    2. M.sc student of Microbiology Islamic Azad University Central Tehran Branch Iran Tehran


  • Introduction: Pregnancy is associated with various physiological changes that continue immediately after conception until delivery. During this period, physiological changes and various hematological manifestations occur in women. During pregnancy, the pregnant mother undergoes significant anatomical and physiological changes. Pregnancy and breastfeeding are physiological periods that lead to an increase in metabolic needs. During pregnancy, an increase in plasma volume and red blood cell mass, as well as an increase in plasma protein synthesis, occur. Also, during this period, a physiological hemodilution occurs, which leads to a decrease in the plasma level of some vitamins, if the plasma level of some vitamins cannot change due to carrier enhancers. Vitamin B12 is essential for maintaining body health and folate metabolism for cell proliferation during this period.
  • Methods: Vitamin B12 is essential for maintaining body health and folate metabolism for cell proliferation during this period. Vitamin B12 is associated with an increased risk of pregnancy and complications and adverse outcomes such as preeclampsia, spontaneous abortion, intrauterine growth spurt, preterm birth, megaloblastic anemia of the newborn, malformation of the fallopian tube, and neurological problems in the newborn. The main observed blood changes include physiological anemia, leukocyte and immunological function, mild thrombocytopenia and coagulation and fibrinolysis. Anemia is the most common blood abnormality in pregnant women, which can lead to maternal and fetal complications. The main cause of anemia in pregnancy is iron deficiency, which increases the need for iron. Physiologically, the most common cause of anemia in pregnancy is iron deficiency anemia, which occurs in order to increase the need for iron during this period.
  • Results: Pregnancy can be associated with numerous hematological manifestations. Rapid diagnosis and early treatment are often necessary to prevent maternal and fetal complications.
  • Conclusion: The number of lymphocytes decreased in the first and second trimester of pregnancy and increased in the third trimester, which is lower compared to non-pregnant women, and then returns to its normal value 4 weeks after delivery. The number of monocytes is higher in pregnancy, especially in the first trimester, but it also decreases as the pregnancy progresses The ratio of monocyte to lymphocyte increased significantly during pregnancy, while the number of eosinophils and basophils did not change significantly during pregnancy. In healthy women with normal pregnancy, there is no change in the absolute number of lymphocytes, as well as the relative number of B and T lymphocytes.
  • Keywords: Pregnancy, anemia in pregnany, hematologic manifestations, bleeding in pregnancy