• Collagen Extraction from Marine Organisms and Its Effect on the Wound Healing Process: A Systematic Review
  • Sara Sabokkhiz,1,* Robab Bahreini,2 Elham Sasan,3 Neda Baghban,4
    1. Student Research and Technology Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    2. Student Research and Technology Committee, Bushehr University of Medical Sciences, Bushehr, Iran


  • Introduction: Collagen is the main component of the extracellular matrix and plays a crucial role in the wound healing process. However, traditional sources of collagen, such as bovine and porcine sources, have several limitations, including the risk of transmitting diseases and ethical concerns. Marine organisms, such as fish and crustaceans, have become an attractive alternative source of collagen due to their abundance and low risk of disease transmission. This systematic review aims to evaluate the effectiveness of collagen extracted from marine organisms in promoting wound healing.
  • Methods: A comprehensive literature search was performed using Google Scholar database. The search strategy included keywords ["marine collagen" or "fish collagen” or "crustacean collagen" or “jellyfish collagen” or “sea cucumber collagen" or “starfish collagen”] and “wound" in title. Only studies published between 2012 and 2022 were included in this review.
  • Results: A total of 22 studies were included in this review. The studies investigated the effects of marine collagen on wound healing both in vitro and in vivo. The results showed that marine collagen has several beneficial effects on the wound healing process, including promoting cell proliferation, improving collagen synthesis, and accelerating wound closure. Moreover, marine collagen was found to have antibacterial properties, which could help prevent infections in wounds.
  • Conclusion: The findings of this systematic review suggest that collagen extracted from marine organisms has potential as an effective wound healing agent. Marine collagen has several advantages over traditional sources of collagen, including low risk of disease transmission and ethical concerns. However, further research is needed to optimize the extraction and purification of marine collagen and to evaluate its safety and efficacy in clinical studies.
  • Keywords: collagen; wound; marine organisms; jellyfish