• Application of Biosensors in the Analysis of Biochemical Markers
  • Niloofar Soleimani,1,* Yasamin Sanati Sichani,2 Alieh Abdolrezaie,3
    1. Young Researchers and Elite Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
    2. Bachelor student of plant biology, Department of Biology, Faculty of Biological Sciences and Technologies, University of Isfahan, Iran.
    3. Department of Biochemistry, Faculty of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.


  • Introduction: Biosensors are biological molecules that have the ability to accurately detect and measure biological molecules and by producing a signal, announces information about the current situation. Recent technological advances have led to the development of this technology and accelerating the process of diagnosing and treating diseases, identifying biomarkers, cancer cells, as well as tracking the response of the patient's body to treatment and direct measurement of biochemical activities in biological samples before and after drug administration. The purpose of this study is to investigate the progress and application of biosensors in order to identify and detect effective biochemical factors in the diagnosis of diseases and their treatment.
  • Methods: In this review study with library methods, relevant articles from databases were studied in order to investigate the application and use of biosensors in the detection of biological molecules, acceleration of the treatment process and analysis of the healing process of diseases.
  • Results: Studies have shown that the use of biosensors for the analysis of biochemical markers in patient samples, due to the accurate detection of enzyme molecules and the evaluation of analytes, provides an opportunity for early diagnosis and treatment of diseases, the presence or absence of biomarkers. It has been found that biosensors play an important role in the detection of specific biomolecules, which will be very useful for new assays of extracellular exosomes, blood biopsies and body fluids of patients with the help of this technology in the field of oncology. Today, with the increase in sensitivity of immunobiochips and the detection of exosomal RNAs, cancer diagnosis is also done, and biosensors based on protein receptors are being investigated. Modern nanotechnology, innovative enzyme engineering, sophisticated sequencing program-based designs, and precise in vivo/in vitro applications for DNA-based biosensors have all facilitated their use but accurate time measurement of metabolite biomarkers still requires the development of in vivo sensors.
  • Conclusion: Considering the functional characteristics of biosensors such as stability, sensitivity and high efficiency in the pharmaceutical and clinical field, its small size and its role in medical applications compared to conventional techniques, its use in early clinical diagnosis with regard to the complex biomarkers of organisms and environmental factors. And genetics is still a big challenge, but its use has led to a new approach in medical science that, with further progress, can increase the quality of life of patients.
  • Keywords: Biosensor, Biochemical Markers, Diagnosis, Treatment, Enzyme Engineering