مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
From Matrix to Enamel: Exploring MMP20 and its Molecular Pathways in Human Tooth Development
From Matrix to Enamel: Exploring MMP20 and its Molecular Pathways in Human Tooth Development
Fatemeh Eslami,1Ali Eslami,2,*
1. Department of cell and molecular biology, Faculty of chemistry, University of Kashan, Kashan, Iran 2. Faculty of dentistry, Tehran university of medical science, Tehran, Iran
Introduction: The role of matrix metalloproteinase 20 (MMP20) in tooth development and enamel mineralization has been extensively studied. This review explores the significant role of MMP20 in human teeth and highlights the design of inhibitors targeting MMP20 as a potential therapeutic approach. Understanding the molecular interactions and mechanisms of MMP20 inhibition opens up new possibilities for dental research and clinical applications.
Methods: A comprehensive literature search was conducted using databases such as PubMed and Web of Science to identify relevant studies. Articles focusing on the role of MMP20 in tooth development, enamel mineralization, and the design of inhibitors were selected and thoroughly reviewed. The selected studies formed the basis for the exploration of the design strategies for MMP20 inhibitors in this review.
Results: Through the analysis of the available literature, it has been established that MMP20 is primarily expressed in enamel-forming cells known as ameloblasts. This enzyme is responsible for the proteolytic degradation of enamel matrix proteins, including amelogenin, ameloblastin, and enamelin, which are essential for proper enamel development. MMP20 activity is tightly regulated and influenced by factors such as pH, proteolytic inhibitors, and other molecules involved in the enamel formation process. The studies analyzed in this review demonstrate that MMP20 plays a critical role in enamel matrix degradation during tooth development. The dysregulation of MMP20 activity has been associated with enamel defects and dental pathologies. Consequently, the design of MMP20 inhibitors has gained attention as a potential therapeutic approach. Promising strategies for inhibitor design include small molecule inhibitors, peptide-based inhibitors, and natural compounds derived from medicinal plants, which have shown inhibitory effects on MMP20 activity.
Conclusion: The design of MMP20 inhibitors presents a promising avenue for dental research and clinical applications. By targeting the activity of MMP20, these inhibitors have the potential to preserve enamel integrity and prevent enamel degradation. Additionally, the design of specific inhibitors may offer new insights into the underlying molecular mechanisms of MMP20 activity and its regulation during tooth development. Further research is needed to optimize the design of MMP20 inhibitors, considering factors such as specificity, stability, and delivery systems, in order to maximize their therapeutic potential. MMP20 regulates the biomineralization process by modulating the activities of other enamel matrix proteins. Additionally, MMP20 interacts with various signaling pathways involved in tooth development, including the Wnt and TGF-β signaling pathways. In conclusion, this review emphasizes the crucial role of MMP20 in tooth development and enamel mineralization. The design of inhibitors targeting MMP20 holds promise for dental research and clinical applications. Understanding the molecular interactions and mechanisms of MMP20 inhibition will contribute to the development of effective therapeutic strategies for the prevention and treatment of enamel defects and dental pathologies. Continued research in this area will further our understanding of the complex processes involved in tooth development and pave the way for innovative approaches in dental care.