مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
The effects of mesenchymal stem cells-derived secretome in cancer prevention and therapy
The effects of mesenchymal stem cells-derived secretome in cancer prevention and therapy
alireza jahazi,1ashtari atefeh,2niazvand firoozeh,3,* Rezaei-Tazangi fatemeh,4kharazi ebrahim,5
1. Student Research Committee, Abadan Faculty of Medical Sciences, Abadan, Iran. 2. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 3. Ilam University of Medical Sciences, Ilam, Iran. 4. Assistant Professor of Anatomical Sciences Department of Anatomical Sciences, School of Medicine Fasa University of Medical Science 5. Assistant Professor of Anatomical Sciences Department of Anatomical Sciences, School of Medicine abadan University of Medical Science
Introduction: Cancer is a leading death reason worldwide, and due to the growing aging population, it is a rising health problem in both developing and developed nations. By rapid advancements in therapeutic methods, using stem cells has provided novel approaches in treating cancer. The secretome term is well-defined as the collective term of the entire set of secreted proteins by cell secretory machinery since the introduction of the term by Tjalsma and coworkers in 2000. All secreted proteins either attached over the cell surface or anchored in the extracellular environment as well as the proteins consisted of the secretory pathway subtitle as the secretome.
Methods: To carry out this review, the key words mesenchymal stem cells (MSCs), Secretome, Cancer, Cell therapy from ISI, PubMed, Scopus databases and Google Scholar were searched. Based on the selection criteria, the articles that were published between 2015 and 2022 were selected and included in the study.
Results: Mesenchymal stem cells (MSCs) have shown growing promise in cancer therapy owing to their advantageous qualities. MSCs secret exosomes via paracrine signaling, which have the same impact as MSCs, as well as having the benefits of remarkable repairability, negligible immunogenicity, and targeted delivery.
Conclusion: In this review, the obtaining procedures, characteristics, biological activities, and recent discoveries regarding the influence of MSCs exosomes in cancer therapy, and a summary of inhibiting as well as promoting role of these cells on cancer progression is provided.