مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
Bioinformatic investigation of miR-29 , miR-96 as genetic regulators in gastric cancer
Bioinformatic investigation of miR-29 , miR-96 as genetic regulators in gastric cancer
Dr.Faramak Jamshidian,1Dr.Shohre Zare,2,*
1. Department of Biology , East Tehran Branch , Islamic Azad University , Tehran , Iran 2. Department of Genetics and Biology , School of Biological Science , Varamin-Pishva Branch , Islamic Azad University , Varamin , Iran
Introduction: Background : Gastric cancer is one of the most common cancers and one of the most frequent causes of cancer-related deaths. The incidence, diagnostic studies, and therapeutic options have undergone important changes in the last decades, but the prognosis for gastric cancer patients remains poor, especially in more advanced stages. Surgery is the mainstay of treatment of this disease.
Methods: First, we examined miR-128 and miR-138 in the comprehensive mirDB database and extracted all the information related to them and their target genes. Then, with the help of Kyoto gene encyclopedia (KEGG Pathway), we studied all the known metabolic pathways and roles of miR-128 and miR-138. Finally, with the help of COSMIC database, we were able to first confirm the role of these miRNAs in gastric cancer and identify all known mutations in them and their regulatory role.
Results: After performing the necessary bioinformatics studies, the regulatory role of miR-29 and miR-96 and their importance in gastric cancer were confirmed. These results showed us that the molecular investigation of miR-29 and miR-96 can have positive results in the regulatory pathways and even the treatment process of gastric cancer.
Conclusion: miR-29 and miR-96 have a positive regulatory role in the process of gastric cancer, and useful results can be obtained by studying them and their target genes.