مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
Legionnaires disease review article
Legionnaires disease review article
Kosar reihanpour baghkhoshki,1,*
1. Baclocher student of Microbiology Islamic Azad University Sirjan , Kerman, Iran
Introduction: Mild to severe pneumonia can result from legionnaires' disease. Legionella species are typically found in contaminated soil and water sources. The summer and fall seasons are when the breakouts typically take place. Respiratory and gastrointestinal symptoms, hyponatremia, and transaminitis are common clinical signs that point to Legionnaires' illness. We describe a patient who developed Legionnaires' illness after becoming overheated.
Typically, 2 to 14 days after bacterial exposure, the symptoms appear. This illness shares several characteristics with typical community-acquired pneumonia. Fever, coughing, dyspnea, headaches, and muscle aches are among the typical symptoms.
Methods: From the patient's sputum, Legionella pneumophila strain Corby was identified. Due to coughing and expectoration for five months and worsening shortness of breath for one and a half months, the patient was admitted to the hospital for 21 days. For bacterial isolation, peripheral blood, sputum, and bronchoalveolar lavage fluid (BALF) were collected. White blood cell count, neutrophil percentage, C-reactive protein, Next-generation sequencing (NGS) data (peripheral blood, bronchoalveolar lavage fluid, and bronchial brushing specimens), and the results computed tomography (CT) data were obtained as part of the patient's clinical information.
Results: The Corby clinical isolate's antibiotic sensitivity was tested. Nine drugs, including ciprofloxacin, levofloxacin, moxifloxacin, erythromycin, azithromycin, clarithromycin, rifampicin, tigecycline, and doxycycline, were shown to be sensitive to the strain, according to the results.
The amount of intracellularly developing L. pneumophila strains Corby and Philadelphia 1 (JR32) was counted after 1.5 hours of co-culture with murine macrophage J774. According to the findings, Corby (ICDC) has a higher capacity for intracellular proliferation than JR32. There were noticeably more intracellular bacteria in the Corby group than in the JR32 group 48 and 72 hours after infection
Conclusion: In the summer and fall, outbreaks of legionellosis are frequent. The illness might cause the involvement of multiple organ systems or just simple pneumonia. High suspicion, prompt diagnosis, and prompt treatment have led to better results, such as faster symptom clearance, shorter hospital stays, and lower mortality.
The disease commonly manifests as gastrointestinal and respiratory symptoms, and according to the literature study, it is typically contracted from drinking water that has been tainted.