مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
Association between Helicobacter pylori Infection and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis
Association between Helicobacter pylori Infection and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis
Elnaz Ezzati Amini,1,*Yousef Moradi,2
1. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. 2. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Introduction: Purpose: This systematic review and meta-analysis summarizes the evidence for the association between Helicobacter pylori infection and primary open-angle glaucoma.
Methods: Methods: Eligible studies reporting an association between H. pylori infection and glaucoma were identified through an extensive search of the Excerpta Medica (EMBASE), Web of Science, Scopus, and PubMed databases, and a review of the reference lists of top articles up until October 2022. The analysis was performed using a random effects model in Stata 17.
Results: Result: The systematic review included 24 studies, comprising 1602 glaucoma patients and 2800 control individuals. The combined relative risks (RRs) of cohort studies and overall combined odds ratios (ORs) of case-control studies demonstrated a significant correlation between H. pylori infection and glaucoma. Subgroup analysis revealed that glaucoma patients had a higher risk of H. pylori infection if they were residents of European countries (Cohort: RR: 1.69; 95% CI: 1.3-2.19) and (Case-Control: RR: 3.71; 95% CI: 2.07-6.64), had primary open-angle glaucoma (POAG) (Cohort: RR: 1.76; 95% CI: 1.37-2.27) and (Case-Control: RR: 3.71; 95% CI: 2.93-4.70), were diagnosed with H. pylori infection using histology (Cohort: RR: 1.95; 95% CI: 1.26-3.01) and (Case-Control: RR: 4.06; 95% CI: 2.28-7.22), and were over 60 years old (Cohort: RR: 1.63; 95% CI: 1.33-2.00) and (Case-Control: RR: 2.95; 95% CI: 2.27-3.83).
Conclusion: Discussion: The meta-analysis results suggest a statistically significant association between Helicobacter pylori infection and primary open-angle glaucoma.