• Beneficial effects of Mangifera indica L extract in reducing symptoms of experimental ulcerative colitis model
  • Seyyed Jamaleddin Tabatabaei aghda,1 Seyyed Meysam Abtahi Froushani,2 Seyyed Abolfazl Tabatabaei aghda,3,*
    1. Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
    2. Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia ,Iran
    3. Department of Operating Room, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran


  • Introduction: In this experimental study, we investigated the clinical effects and immune responses of the hydroalcoholic extract of Mangifera indica L (MIE) in an animal model of ulcerative colitis. Mangifera indica L, commonly known as mango, is a fruit rich in tannins that has been proposed as a potential alternative strategy for the prevention of auto-inflammatory diseases and colon cancer due to its anti-inflammatory properties.
  • Methods: We randomly assigned thirty-two adults male Wistar rats into four groups of eight, including a healthy control group, a patient control group, a patient group receiving prednisolone (2 mg/kg PO), and a group receiving mango extract (150 mg/kg PO). Ulcerative colitis was induced in the rats by intrarectal injection of acetic acid. After confirming the induction of the disease, the rats underwent a ten-day treatment period during which animals in the gavage groups were administered their respective treatments. At the end of the treatment period, the rats were euthanized in a humane manner, and blood serum and colon tissue samples were collected.The obtained results were analyzed using one-way analysis of variance and disease activity index, anti-inflammatory activity were evaluated by measuring tissue myeloperoxidase (MPO) activity, colon tissue lipid peroxidation (MDA) levels using thiobarbituric acid reactive substances (TBARS), and tissue nitric oxide (NO) activators. Additionally, disease severity and tissue inflammation were assessed by measuring total protein levels.
  • Results: The results of this study indicate that both treatment modalities, namely plant extract and prednisolone, exhibited efficacy in reducing the intensity of clinical symptoms associated with ulcerative colitis.In the study, it was observed that Mangifera indica L extract displayed significant anti-inflammatory properties. The extract was found to decrease the elevated levels of MPO, NO, MDA, and total protein in the blood serum with a significant difference, which suggests its potential for reducing the severity of the disease. Additionally, the study found that Mangifera indica L extract was more effective than prednisolone in reducing the increased levels of MDA and total protein in the blood serum with a significant difference.
  • Conclusion: Notably, treatment with Mangifera indica L plant extract is associated with fewer side effects compared to prednisolone. Overall, these data support the notion that Mangifera indica L extract may be utilized as a natural-source treatment strategy for reducing the symptoms of ulcerative colitis.
  • Keywords: Ulcerative Colitis, herbal extract, Anti-Inflammatory effects, Mangifera indica L,Wistar rats.