Therapeutic impact of Ozone administration on Breast cancer treatment: a comprehensive review
Therapeutic impact of Ozone administration on Breast cancer treatment: a comprehensive review
Fatemeh Mokhles,1Shakiba Asgari,2Eshagh Sedighi,3Negar Ziaei,4Masoume Bakhshi,5Ali Samadi,6,*
1. Department of Molecular Medicine, Institute of Medical Biotechnology (IMB), National Institute of Genetic Engineering and Biotechnology (NIGEB), P.O Box 14965/161, Tehran, Iran. 2. Department of Biology, Tehran central branch of Islamic Azad University, Tehran, Iran 3. Department of Veterinary medicine, Urmia branch of Islamic Azad University, Urmia, Iran 4. Institute of Biotechnology, Isfahan University of technology, Isfahan, Iran 5. Institute of Biotechnology, Isfahan Royan Institute, Isfahan, Iran 6. Department of Basic Sciences, School of Medicine, Bam University of Medical Sciences, Bam, Iran
Introduction: Breast cancer as a highly heterogeneous disease increases the death rate worldwide over time. For the last decade, studies have shown that ozone therapy has an anti-proliferative effect on cancer cells without affecting non-cancerous cells. The mechanism is to increase the blood oxygen level, reducing tumor hypoxemia. Accordingly, researchers extended investigations in in-vitro, in-vivo, animal models, and clinical studies of solid tumors, including breast cancer.
Methods: Herein we considered assessing ozone therapy's overall impact in recent contributed literature on cancer with specific insights on breast cancer.
Results: Many studies provided evidence of ozone therapy’s immunomodulatory impact and sensitizing effect on chemotherapy and radiotherapy. Also, ozone therapy seems to help fatigue relief in cancer patients and cancer resection healing. Although the FDA did not provide any agreement to ozone administration in cancer patients, it elucidated that ozone is a harmful and toxic air pollutant. By that intravenous administration of ozone resulted in pulmonary embolism and death, it is critical to assess if the recent investigations prove the security and efficacy of therapeutic ozone in cancer. Besides, ozone accurate delivery is crucial. Nowadays ozone is considered a complementary treatment in many conditions at the clinical level and some administration approaches in the hands of specialists achieved their safety and efficacy profile.
Conclusion: In conclusion, ozone therapy in breast cancer profile suffers from a lack of investigations and clinical studies. Many reviewed literature have claimed that ozone is safe and effective in case of breast cancer treatment, even as integrative therapy or palliative therapy to increase the quality of life. However, it is essential to conduct more investigations and more clinical experiments to conduct systematic reviews of randomized controlled trials (RCT) studies.