• Exosomes and it’s role in the prognosis and therapy for prostate cancer
  • Ali Zarei,1,* Hossein Javid,2 Abolfazl Khalafi-nezhad,3 Sara Sanjarian,4
    1. Department of Human Genetics, Iranian Academic Center for Education, Culture and Research (ACECR)-Fars Branch Institute for Human Genetics Research, Shiraz, Iran
    2. Department of Human Genetics, Iranian Academic Center for Education, Culture and Research (ACECR)-Fars Branch Institute for Human Genetics Research, Shiraz, Iran
    3. Department of Hematology, Medical Oncology and Stem Cell Transplantation, Shiraz University of Medical Sciences, Shiraz, Iran
    4. Department of Human Genetics, Iranian Academic Center for Education, Culture and Research (ACECR)-Fars Branch Institute for Human Genetics Research, Shiraz, Iran


  • Introduction: Prostate cancer is a common cancer in men and primarily affects men over 50 years of age. Prostate cancer is the third most prevalent cancer in men worldwide and the sixth most prevalent in Iran. Since the survival rate for people whose prostate cancer has spread to other parts of their body is low, By using new methods, they can survive longer or even be completely healed.Exosomes, which are extracellular vesicles, have received a lot of attention from oncologists recently.
  • Methods: Literature Review
  • Results: The regulation of immune response, cell stability, tissue repair, and cancer progression are just a few of the vital biological functions that exosomes are involved in. Exosomes affect cancerous cells through their communication between cells and the transfer of molecules. Two issues arise when trying to use exosomes to manage cancer treatment: cancer diagnosis and drug delivery system. With respect to the first issue, invasive methods often endanger the life of the patient. By replacing the exosome detection method with an invasive method as a biomarker, these risks can be greatly reduced. On the other hand, exosomes can be a suitable option for drug delivery due to their stability, biocompatibility, permeability, and low toxicity.
  • Conclusion: Exosomes can be used through drug administration as well as biomarkers for prostate cancer treatment, but further studies are needed for clinical efficacy.
  • Keywords: Prostate Cancer, Exosome, Diagnostic, Drug Delivery