The effects of L-serine on oxidative stress of pancreas in diabetic mice
The effects of L-serine on oxidative stress of pancreas in diabetic mice
Mahshad Sheikhi Narani,1Akram Vatannejad,2,*
1. Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran 2. Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Introduction: Diabetes mellitus is a metabolic disorder with an increasing global prevalence that can lead to premature death. High blood glucose is the main symptom of diabetes mellitus as a consequence of disorder in pancreatic insulin secretion or function. L-Serine supplementation -regarded as safe by the FDA- can improve glucose homeostasis, and can reduce homeostasis model assessment-estimated insulin resistance (HOMA-IR) and oxidative stress. The aim of this study was to investigate the effects of L-serine intake on oxidative stress indices in the pancreas of diabetic mice.
Methods: 18 c57bl/6 male mice were divided into 3 groups (control, diabetic control and diabetic mice treated by L-serine(. Diabetes induced by chemical method (streptozotocin, 200 mg/kg). After four weeks of oral administration of L-Serine (approximately 280 mg/day/mouse), animals were euthanized by guillotine and blood samples were collected to determine biochemical parameters and oxidative stress indices.
Results: The results of this study showed that the oral administration of L-Serine in diabetic mice could help to lower blood sugar level and could lead to increased catalase activity as a free radical scavenger (p<0.05) but had no significant effect on the level of Malondialdehyde as an end product of lipid peroxidation in oxidative stress status.
Conclusion: These findings show that the supplement of L-Serine may has an effective influence on diabetes-induced pancreas damage by lowering blood sugar and improving oxidative stress status.