kosar reihanpour,1Saman Hakimian,2,*
1. Baclocher student of Microbiology Islamic Azad University Sirjan Sirjan, Kerman, Iran 2. M.sc student of Microbiology Islamic Azad University Central Tehran Branch,Iran,Tehran
Introduction: Introduction:
Lassa fever(LF), The cause of acute viral hemorrhagic disease is the Lassa virus (LASV). Exposure toMastomys natalensis, the rodent host, contaminated feces or urine, is the primary cause of infections in humans.Environmental elements, such as being close to vegetation, forests, and garbage, enhanced the likelihood of LASV exposure
The family Arenaviridae includes the virus that causes Lassa fever
Lassa fever has been linked to several rodent species, including Hylomyscus pamfi and Mastomys erythroleucus.Every year, LAV results in 5,000 fatalities.Since 2010, there have been more documented cases of LF.
Methods: Material methods:
The Lassa virus (LASV), a single-stranded RNA arenavirus encapsulated, bipartite, is what causes Lassa fever
This RNA virus has a typical diameter of 110 to 130 nm and has a spherical or rounded shape
The smaller segment's precursor nucleoprotein and glycoprotein, as well as the more significant segment's RNA-dependent RNA-polymerase and matrix RING Zincfinger protein, are the four proteins that the RNA .genomes encode
virulence and pathogenesis factors
LASV is a negative-sense, single-stranded RNA virus with an envelope. The large and small parts of the genome each contain two ambisense regions.
Results: Results:
Negative effects from Lassa virus infection are particularly likely to affect pregnant women and their .unborn children
According to a recent assessment, pregnant women have a three times higher chance of dying from Lassa .fever than non-pregnant women
Factors Affecting the Reemergence of Epidemics of Lassa Fever
Migration, travel, and nosocomial transmission
Systems of public health
Environment and Climate
Effects of Conflicts and Civil War
Conclusion: Conclusion:
Poor outcomes among Lassa fever virus-infected pregnant women are mostly brought about by immune changes during pregnancy or the virus' attraction to the highly vascularized placenta. The patient's prognosis could get worse if medical treatment is postponed. Additionally, overlapping clinical symptoms including headaches, vaginal bleeding, and tummy pain in pregnant women might make it difficult to diagnose Lassa fever
Particularly in endemic locations, the ecology of the Lassa virus and its interaction with humans, as well as the development of Lassa fever, are complex.
At the moment, ribavirin, an antiviral medication, is . the only available specialized treatment.
Keywords: Lassa fever(LF),stable signal peptide (SSP) ,pathogenesis, ribavirin, infectionstable