Introduction: Oxidative stress (OS) is a chemical mismatch between an oxidant and an antioxidant that causes damage to redox and control or causes molecular damage. Imbalanced oxidative metabolism can produce a variety of reactive species (ROS). These ROS can cause severe changes in platelet metabolism and affect platelet function.
It also leads to increased platelet procoagulant phenotype and cell apoptosis, which increases the risk of thrombosis. The generation of ROS and the subsequent activation, adhesion and recruitment of platelets are further encouraged in an auto-reinforcing loop by platelet-generated ROS. Meanwhile, cancer cells produce a higher concentration of ROS due to their fast metabolism and high proliferation rate.
However, excessive ROS can lead to damage and modification of cellular macromolecules. Cancer formation and progression are strongly related to oxidative stress and oxidative damage. In addition, platelets are an important part of the tumor microenvironment and there is a significant interaction between platelets and cancer cells.
Methods: Cancer cells change platelet activation status, RNA spectrum, proteome and other properties. Excess ROS can damage cellular lipids, proteins, or DNA, altering their normal function and triggering inflammatory responses. In 1865, the association between platelets and cancer was named Trousseau syndrome.
Drug studies have shown that aspirin, clopidogrel, and ticagrelor all inhibit platelets, but while they inhibit platelets, many platelet functions are also impaired.
The interaction between tumor cells and platelets leads to platelet activation, which causes the release of factors that lead to tumor cell survival and proliferation.
Results: Drug studies have shown that aspirin, clopidogrel, and ticagrelor all inhibit platelets, but while they inhibit platelets, many platelet functions are also impaired.
The interaction between tumor cells and platelets leads to platelet activation, which causes the release of factors that lead to tumor cell survival and proliferation.
Conclusion: Progression has been widely studied, and they not only promote the metastasis of tumor cells, but also have an inhibitory effect. Therefore, in-depth research and summary of the molecular mechanism of platelets in tumor cell metastasis is of great importance for the screening and treatment of cancer patients.