Clinical methods of Alzheimer’s treatment: A Systematic review
Clinical methods of Alzheimer’s treatment: A Systematic review
Alireza Parizad,1,*Farzad Nezafati,2
1. 12th grade(Experimental Sciences),Noor Research institue , County of Shabestar, Province of East-azarbayjan, Iran 2. Department of biology, Kermanshah branch, islamic azad university, kermanshah, iran
Introduction: Alzheimer's disease is a neurodegenerative disease caused by amyloid beta protein. According to the statistics of the World Health Organization, it is predicted that the prevalence of Alzheimer's disease will increase four times by 2050, while today it is the fifth cause of death among people over 65 years old. This disease imposed a lot of treatment costs on countries, and no cure was found for this disease
Methods: We systematically reviewed Alzheimer's clinical studies with the aim of identifying a better and effective way to treat Alzheimer's disease. For this purpose, English language clinical trial articles between 2017 and 2023 were searched in PubMed, Cochrane and Science Direct databases. The titles of the articles were scanned with keywords “Alzheimer's” and “treatment”.
Results: After studying the abstract, conclusion, results and discussion sections of the selected articles, into five categories: 1) Radiation and electromagnetic therapy, which in this method enhances cognitive function. 2) Biomarkers, in this method, with the help of these biomarkers, drugs are provided that identify destructive proteins in the brain and can slow down or eliminate Alzheimer's disease. 3) Antibody, for example Donanemab, which targets the amyloid beta protein in the brain and destroys it. 4) A hormone, for example, the incretin hormone GLP-1, which causes the recovery of glucose in the blood-brain barrier, which in turn leads to the protection of Alzheimer's against cognitive disorders. 5) A drug that was seen to have effects on behavioral performance and Alzheimer's improvement in this method; Was divided. Among the 28 articles that entered the study phase, 4 articles are in the first category, 2 articles in the second category, 1 article in the third category, 2 articles in the fourth category and 19 articles in the fifth category. In this research, 14.2% of treatment methods are related to the first category, 7.1% are related to the second category, 3.5% are related to the third category, 7.1% are related to the fourth category and 67.8% are related to the fifth category.
Conclusion: It seems that according to the above research methods, there is a prospect of improving the treatment of Alzheimer's disease, but each of them has challenges such as lack of time and small sample size. In general, the clinical trials conducted on Alzheimer's disease were mostly medicinal.