Farzaneh Ramezani Hombari,1,*Faranak Jamshidian,2Maryam Rouhani,3
1. Department of Biology , East Tehran Branch, Islamic Azad University , Tehran ,Iran 2. Department of Biology , East Tehran Branch, Islamic Azad University , Tehran ,Iran 3. Department of Tissue Engineering and Applied Cell Sciences , School of Advanced Technologies in Medicine , Shahid Beheshti University of Medical Sciences,Tehran,Iran
Introduction: The high prevalence of obesity and its associated diseases is a major problem worldwide. Genetic predisposition and the influence of environmental factors contribute to the development of Obesity.
Obesity is a complex multifactorial abnormality that has a well-confirmed genetic basisHowever, the problem still lies in identifying the genes linked to body mass and composition.
There fore, ,this study aimed to analyze associations between genes FTO,FABP2,LEPR,MC4R and LEP.
Methods: In this review, variants in genes associated with adipocyte function are examined but variants are in genes associated with metabolic aberrations and the accompanying disorders in visceral Obesity Overexpression of FTO in the diet with the positive regulation of lipogenic genes causes an increase in triglycerides and the prevalence of metabolic syndrome is strongly related to Obesity.
Results: Therefore it is associated with high food consumption, especially a high-calorie, high-carbohydrate diet, as well as the expression of genes involved in lipolysis
Conclusion: Based on This Genes, Each Person’s Diet& Life Style Can be Determined.