Introduction: Vulvovaginit is one of the most widespread gynecological disorders among adolescent and childhood female.The vaginal environment is home to numerous microorganisms who have mutualistic relationships with each other and their hosts. Lactobacillus species as an indicator species among the natural microorganisms in the vaginal environment is responsible for the production of antimicrobial compounds such as hydrogen peroxide, lactic acid and bacteriocin-like substances. Vaginitis occurs when the micro-organisms unbalanced in the vaginal environment finally vaginal environment are favorable to the growth of anaerobic bacteria and producing lactic acid and hydrogen peroxide by the Lactobacillus species. Lactic acid produced by lactobacillus causes acidification of the vaginal environment with PH (3.5-4.5) which promotes Lactobacillus ssp. The polymicrobial biofilm in the vaginal epithelium could be created by the microorganism in vaginosis. The usual type of vulvovaginit are bacterial vaginosis (BV), candida vaginitis (CV), Trichomonas vaginalis (TV).Volvovaginit treatment is normally prescribed using antibiotics such as metronidazole, clindamaysin for BV and azole group for CV Although the treatment shows to be effectively remedied and alleviate signs and symptoms of infection in the long term but there is a possibility of relapse of infection very common. Therefore, the use of alternate therapies is suggested, which includes 1. Home remedies 2.Phytotherapy 3.Lactobacillus therapy 4. Vaginal douche 5. Yogurt therapy 6.Treatment with honey, royal jelly and propolis are bee products that have antimicrobial properties due to their flavonoid and phenolic compounds. They are used in the treatment of vaginitis. Other new strategies to increase the rate of treatment for vaginitis include the use of prebiotics, probiotic, acidifying agents, antiseptics, vaginal microbiota transplantation, and phage endolysins.
Methods: Use of the antibiotics causes to distribute normal flora vagina and reduce lactobacillus and other microorganism of the normal flora vagina and could more grow fungi and bacteria finally increase resistance to antibiotics. Past research show use natural materials for treatment vaginit in addition to the inhibitory properties of microorganisms, it improves the symptoms of disease and prevent the recurrence of the symptoms of disease.
Results: The treatment of infection vaginitis whit antibiotics has acceptable results however whit high recurrence rate after treatment.. Natrule trapy vaginitis is the reduction of side and systemic effect and decline the risk of bacterial resistance.
Conclusion: The high recurrence of infection vaginitis is attributed to several reasons, including an increase in bacterial resistance to certain antibiotics 2. The presence of biofilm infection decreasing the effect of antibiotics and produces non-sensitive species 3.The presence of a biofilm in the infection makes hard to wipe out the infection 3.More than one species led to reduction anti-microbial properties to kill bacteria and wipe out biofilm. Formulation of antibiotic recommend for vaginitis are not efficient because of their leaking, lack of proper drug release or short stay in the vagina. Treatment of vaginit by natural compounds are effective whit out harmful effect and whit out disrupt in the natural flora of vaginal.