Clinical Implications of Subclinical Hypothyroidism on Sperm Quality: A Systematic Review and Meta-Analysis
Clinical Implications of Subclinical Hypothyroidism on Sperm Quality: A Systematic Review and Meta-Analysis
Mojtaba Aghaei,1,*Seyed Sobhan Bahreiny,2Mohammad Mehdi abolhasani,3Mohammad Reza Dabbagh,4Ehsan Sarbazjoda,5Mohammad Sharif Sharifani,6
1. Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2. Ahvaz, Iran, Azadegan St 3. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 4. Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. 5. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 6. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Introduction: Background: Cytokines such as tumor necrosis factor alpha play roles in the tumor microenvironment by affecting aspects of cancer progression. The goal of this study was to investigate how these cytokines impact tumor cell growth and spread through methods and a systematic review.
Methods: Methods: We conducted experiments using both laboratory and animal models to assess how TNF α influence tumor cell proliferation, invasion and metastasis. Additionally we performed a review by analyzing existing literature to gather evidence on the role of these cytokines in cancer progression.
Results: Results: Our findings from the experiments showed that TNF α have effects on different types of cancers. While some cytokines promote cell growth others exhibit effects. Moreover these cytokines demonstrate nuanced roles in tumor metastasis by influencing migration and invasion capabilities. The systematic review supported these multifaceted roles by highlighting context influences on tumor progression across malignancies.
Conclusion: Conclusion: This comprehensive study provides insights into the relationship between TNF α in terms of tumor cell growth and metastasis. It emphasizes that their effects are specific, to the context in which they occur. These findings highlight the possibility of using modulation as a basis, for therapeutic approaches, which opens up exciting prospects for further research and the development of cancer treatments, in the future.