The role of gene polymorphisms in brain tumor pathogenesis and its implications for personalized medicine
The role of gene polymorphisms in brain tumor pathogenesis and its implications for personalized medicine
Shokoofe Gerivani,1Mahla Rafat,2Fateme Karami,3,*
1. Department of Biology, College of Convergent Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran 2. Department of Biology, College of Convergent Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran 3. Department of Medical Genetics, College of Medical Sciences and Technologies, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
Introduction: Brain and other nervous system cancer is the 10th leading cause of death for men and women. Various genetic factors play an important role in the occurrence of brain tumors,and among these genetic factors, there are polymorphisms that are more important than others, and in this review article, we have discussed the role of these polymorphisms in brain tumor pathogenesis and its implications for personalized medicine.
Methods: An advanced literature search was conducted in PubMed, Google Scholar and Embase
databases. Searching was included following keywords: brain tumor, gene
polymorphism,personalized medicine. All the articles since 2000 was included in the present study.
Results: Polymorphisms of the ALAD(G177C), TERT(rs2853676) , EGFR(rs4947986), TP53(Arg72pro) genes are the most important genetic factors behind brain tumor pathologies which allowing for tailored treatment strategies and improved prognostic assessments
Conclusion: Considering found significant gene polymorphisms not only can identify predisposed
individuals at earlier stages, but also can be implicated in the targeted therapy and follow up of the brain tumor patients.