Investigating the replacement of postbiotics in people sensitive to probiotics: a systematic review
Investigating the replacement of postbiotics in people sensitive to probiotics: a systematic review
Zahra Bayat Sarmadi,1,*Fatemeh Bayat Sarmadi,2
1. Department of microbiology, Faculty of biology, Alzahra University, Tehran, Iran 2. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
Introduction: The use of probiotics has become popular in recent years for the treatment of digestive diseases. However, there are reports of sensitization in certain groups of people. Postbiotics are the metabolic side products of probiotics, which have been considered as an alternative to probiotics in these people. This systematic review was conducted with the aim of evaluating the effect of postbiotics in people sensitive to probiotics.
Methods: The keywords "Probiotics", "Postbiotics", "Probiotics sensitivity" and "Digestive diseases" were used in a comprehensive search of databases such as PubMed, Scopus, Web of Science, Google Scholar and Science Direct to find studies aimed at investigating the effect of postbiotics. It was done in people sensitive to probiotics. During this research, the studies that met our desired criteria were analyzed.
Results: In total, among the 77 articles resulting from the search, finally 25 articles were included in the study based on matching the input and output criteria for data extraction. Based on the data obtained, post-biotics are effective in reducing the symptoms of people sensitive to probiotics, including bloating, gas and diarrhea. However, evidence for their effectiveness in other gastrointestinal symptoms was limited. This study also showed that the use of different concentrations of postbiotics have different effects on gastrointestinal symptoms.
Conclusion: The results of this study show that postbiotics may be a potential alternative to probiotics in people sensitive to probiotics. However, more studies, including case-control studies and group studies, are needed to determine the types of postbiotics and their optimal concentrations to investigate these special conditions. In addition, it is necessary for specialists in this field to consider the individual characteristics of the patient when prescribing postbiotics to reduce gastrointestinal symptoms in people sensitive to probiotics.