• Recent Advances in Application of Fucoidan in Wound Healing: A Systematic Review
  • Fatemeh Mohajer,1 Tuba Zendehboudi,2 Sara Sabokkhiz,3 Robab Bahreini,4 Neda Baghban,5,*
    1. Student Research and Technology Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    2. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    3. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    4. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    5. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran


  • Introduction: Wound healing is a complex process that involves multiple cellular and molecular events. Fucoidan, a sulfated polysaccharide found in brown seaweed, has been shown to have anti-inflammatory, antioxidant, and immunomodulatory effects. The aim of this systematic review is to evaluate the potential of fucoidan as a therapeutic agent for wound healing.
  • Methods: A comprehensive search was conducted using PubMed from inception until May 2023. Studies that investigated the effects of fucoidan on wound healing in animal models or in vitro were included.
  • Results: A total of 51 studies were included in this review. All studies were conducted on animal models or in vitro and evaluated the effects of fucoidan on wound healing parameters such as wound closure rate, angiogenesis, collagen deposition, and inflammatory response. The results consistently demonstrated that fucoidan supplementation improved wound healing outcomes, including increased wound closure rate, enhanced angiogenesis, increased collagen deposition, and decreased inflammatory response.
  • Conclusion: Fucoidan has potential as a therapeutic agent for wound healing. The antiinflammatory, antioxidant, and immunomodulatory effects of fucoidan may contribute to its beneficial effects on wound healing outcomes. Further studies are required to investigate the safety and efficacy of fucoidan in human subjects with various types of wounds. Fucoidan may represent a promising complementary therapy for wound healing
  • Keywords: fucoidan, wound healing