Mohammad Reza Mohammadi,1,*Amir Hossein Omidi,2
1. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2. Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran
Introduction: Pathogenic bacteria cause various infectious diseases worldwide, especially affecting people with weakened immune systems and susceptibility to other infectious diseases. MicroRNAs (miRNAs) are constrained non-coding RNAs that control gene expression at the post-transcriptional level. They are expressed by eukaryotic cells and play essential roles in shaping cell differentiation and organismal development. In addition to being involved in various physiological and pathological processes, including viral infections, microRNAs are increasingly involved in eukaryotic responses to bacterial pathogens. It is becoming increasingly clear that miRNAs are an essential part of host responses to microorganisms.
Methods: We used the words ‘MicroRNAs’, ‘ bacterial infections, and ‘ non-coding RNA ’ in the published data in PubMed, Scopus, and Google Scholar databases for this study.
Results: This study addresses our current understanding of the role of miRNAs in responding to bacterial pathogens.
Conclusion: The use of dysregulated miRNAs in bacterial infections may be an approach to improve the diagnosis, prevention, and treatment of infectious diseases.
Keywords: MicroRNAs, non-coding RNA, bacterial pathogens, immune systems