Introduction: Antibiotic resistance is a critical global health threat, potentially causing millions of annual fatalities in the near future due to the overuse of antibiotics, leading to the emergence of drug-resistant bacteria. Researchers are responding by exploring innovative "resistance-resistant" therapeutic strategies.
Methods: review
Results: These include using compounds to reduce mutagenesis, employing antibiotic cycling and evolutionary steering to make bacteria more susceptible, and developing combination therapies to target defensive mechanisms. Future directions involve leveraging machine learning and personalized medicine. This review also emphasizes the urgency of curbing antibiotic resistance in humans, offering strategies such as reducing colonization by drug-resistant bacteria, enhancing colonization resistance, and mitigating the transfer of resistance genes.
Conclusion: Adopting an interdisciplinary one-health approach is crucial for comprehensive bacterial resistance prevention and control.