• Evaluation of EGFR expression in Odontogenic lesions: A comparative study between “Amaloblastoma and Odontogenic keratocyst”
  • Soheila Mirzaee,1,* DR. reyhaneh shoorgashti,2 DR. Donya Sadri,3 DR. Sareh Farhadi,4
    1. ISLAMIC AZAD UNIVERSITY Tehran Branch Faculty of Medical Sciences - Department of Dentistry
    3. ISLAMIC AZAD UNIVERSITY Tehran Branch Faculty of Medical Sciences - Department of Dentistry
    4. ISLAMIC AZAD UNIVERSITY Tehran Branch Faculty of Medical Sciences - Department of Dentistry


  • Introduction: Introduction: Ameloblastoma (AM) and odontogenic keratocyst are common odontogenic lesions that have a high rate of recurrence. Considering the determining role of epidermal growth factor receptor (EGFR) in cell proliferation and survival of epithelial cells and the controversial results of previous studies regarding the expression of this marker in odontogenic cysts, this study aimed to compare the expression of EGFR marker in AM and OKC.
  • Methods: Methods and Materials: In this study, 46 specimens (20 AM and 26 OKCs) were evaluated; 5-µ sections were prepared for Immunohistochemical staining using EGFR antibody. Immunohistochemical analysis was performed using super sensitive one-step polymer-HRP. The expression of EGFR was first evaluated by quantitative assessment via measuring the count of stained cells in the three stained layers in AM (ameloblastoma-like cells, Stellate reticu, and all layers) and OKC (basal layer, suprabasal and basal layers, and all layers). Next, the mean percentage of stained cells in each specimen was scored and classified
  • Results: Results: The mean percentage of EGFR expression was 81,39±10,41% in the AM and 78.05±19.27 in the OKC specimens. The EGFR expression was significantly no different between AM and OKC according to Mann-Whitney. However, the Mann-Whitney test showed no significant difference in the EGFR score (P=0.141). The chi-square test revealed no significant difference in EGFR expression in different layers (P=0.303).
  • Conclusion: Conclusion:The EGFR expression showed no significant difference between AM and OKC. However, evaluation of other effective growth factors is also imperative
  • Keywords: epidermal growth factor receptor (EGFR), Ameloblastoma (AM), Odontogenic Keratocyst (OKC), odontogen