• Personalized Vaccines using Nanoparticle Carriers: Revolutionizing the Fight against Helicobacter pylori-induced Gastric Infections
  • Firouzeh Honarmand,1 Niloofar Soleimani,2 Erfan Hadizadeh,3,* Alieh Abdolrezaie,4
    1. Young Researchers and Elite Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
    2. Young Researchers and Elite Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
    3. Department of Genetics and cellular and molecular, Faculty of Biology,Science and Research Branch, Islamic Azad University, Tehran, Iran.
    4. Department of Biochemistry, Faculty of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.


  • Introduction: Helicobacter pylori (H. pylori) is a bacterium that annually affects a significant portion of the global population, leading to various gastric diseases. However, the emergence of antibiotic resistance has posed challenges in effectively treating these infections. In response, researchers have turned to specialized methods of medical biotechnology to propose alternative solutions. One promising strategy involves the development of personalized vaccines that take into account individual characteristics, with nanoparticles serving as carriers to enhance the immune response. The aim of this review study is to comprehensively explore the development of personalized vaccines against H. pylori-induced gastric infections, specifically focusing on the utilization of nanoparticles as vaccine carriers.
  • Methods: To conduct this review, relevant information from reliable sources and scientific articles in the fields of medicine, biotechnology, nanotechnology, and biological sciences was extracted. A comprehensive search was performed using databases such as PubMed, Web of Science, and Scopus. The inclusion criteria focused on articles published within the last 10 years and written in English. The search strategy specifically targeted studies related to the development of personalized vaccines against H. pylori-induced gastric infections, with an emphasis on the utilization of nanoparticles as vaccine carriers.
  • Results: Studies indicate that medical biotechnology, through introducing innovative techniques, has brought about the most revolutionary advancements in the field of producing effective vaccines against H. pylori. Designing and developing personalized vaccines based on genetic sequences, physiological characteristics, and individuals' medical histories, using advanced molecular techniques, has enabled us to precisely identify specific antigens of this bacterium. In this regard, antigens possessing suitable biochemical and biological properties are selected and presented as vaccines in combination with effective carriers. In this domain, nanoparticles, due to their specific physicochemical and surface properties, are capable of influencing cells and bacteria, serving as carriers for antigens and vaccine adjuvants. These compounds are transferred to immune cells to enhance the effectiveness and stimulation of the vaccine's immune response in the individual, thus aiding in reducing vaccine-related side effects.
  • Conclusion: Personalized vaccines against H. pylori utilizing nanoparticles as carriers offer a promising strategy for combating this bacterium. Medical biotechnology and advanced molecular techniques have facilitated the identification of specific antigens for personalized vaccine design. Nanoparticles possess specific properties that make them ideal carriers, enhancing immune response and reducing potential side effects. This approach presents a novel solution, particularly in the context of increasing antibiotic resistance. Further research is necessary to optimize the efficacy and safety of these personalized vaccines.
  • Keywords: Medical Biotechnology, Personalized Vaccines, Helicobacter Pylori, Nanoparticles, Gastric Infection