Atena bazjoo,1,*
1. Department of Microbiology, Faculty of science, Islamic Azad University Arak branch, Arak, Iran
Introduction: Dermal wound healingis a complex biological process, which includes four overlappingsteps. These are the in?ammatory phase immediately after thelesion has occurred, the migratory, proliferative and maturationphase resulting in remodeling
Methods: The chitosan solution (10%) was added
to supernatant Bifidobacterium . For wound treatment investigation, 45 male wistar rats divided in 3 groups; control
negative (without treatment), chitosan film group, and chitosan/supernatant film group. A full thickness
wound was created on the back of the animals and treated with corresponding wound dressing. After direct
measurement of wound diameter, 3 rats were sacrificed from each group on day 3, 7, 14 and 21. The wound
healing process was identified by histological analysis
Results: Our results
showed in treatment accelerates the wound healing process by reduce the inflammatory phase , and the proliferative phase starts sooner in the wound healing process.
Conclusion: chitosan/probziotic can be used as wound dressings to promote wound healing.