مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Sjogrens syndrome
Sjogrens syndrome
Mahdieh Ramezani,1,*Mahdi Akhondi,2Milad Ramezani,3
1. Payam Noor Torbat Heydarieh University 2. Assistant Professor, Department of Biology, Payame Noor University, Tehran, Iran 3. Torbat Heydarieh University
Introduction: Sjögren’s syndrome (SS) among primary autoimmune rheumatic diseases encountered by rheumatologists is unusual. Dominated by the pathology of exocrine glands of the eyes, mouth, and exocrine glands along with the presence of multiple specific autoimmune organ disorders, it leads to a somewhat unfamiliar diagnostic and therapeutic outlook. The lack of diagnostic criteria, global classification, and accepted outcomes, as well as the need for close collaboration with subspecialists in ophthalmology, dentistry, and otolaryngology for optimal patient management, all pose challenges in care. Nevertheless, SS offers rheumatologists and immunologists an opportunity to understand the pathogenesis, long-term evolution, and outcome of an autoimmune disease characterized by specific organ and systemic features. Furthermore, the recurrent co-occurrence of SS with other major rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, and scleroderma provides a unique insight into the genetic, environmental, and biological factors controlling autoimmune phenotypes among affected individuals. The striking tissue associations between primary SS and non-Hodgkin lymphoma offer valuable insights into the relationships between autoimmunity, immunogenetics, and malignancy. Significant efforts have been made in treatment for glandular and systemic manifestations of SS. As an autoimmune disease, the prevalence of Sjögren’s syndrome varies in different populations. Accurate data on its prevalence in Iran may be variable, but research estimates the prevalence of Sjögren’s syndrome in Iran to be around 0.5 to 1% of the population. This rate may vary in different regions of the country and be influenced by local factors such as environmental and genetic variables. The average prevalence of Sjögren’s syndrome in women is almost 9 times higher than in men. This gender difference in disease occurrence may be due to the influence of hormones and genetic factors related to endocrine gland tissues. Additionally, women may be more likely to seek hormonal therapies for endocrine gland-related issues, which could contribute to the increased prevalence of Sjögren’s syndrome in them. Understanding Sjögren’s syndrome is crucial as it can aid in the early diagnosis and appropriate treatment of this autoimmune disease. Recognizing this syndrome, which is an autoimmune disorder that attacks the thyroid gland, is of paramount importance as it can lead to quicker symptom control and prevention of serious complications such as thyroid gland damage, increased risk of other diseases, and even premature birth.
Methods: Collecting information from authoritative articles on Google Scholar and NCBI sites and other authoritative scientific sites and categorizing them
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The main goal of this article is to examine the challenges and concerns related to genetically engineered plants and animals. This article examines the environmental, economic, social and ethical effects of these changes and provides solutions and suggestions for the optimal management of these challenges. This not only helps us to exploit the potential of these technologies, but also supports the various opinions of society and the protection of the environment.
Conclusion: Sjogren's syndrome is an autoimmune disease that attacks the body's fluid-producing glands, especially the salivary and eye glands. Diagnosis of this disease is made through clinical history, symptoms, and diagnostic tests, including blood tests, thyroid ultrasound, and imaging tests.
Treatment of Sjogren's syndrome usually involves taking hormonal drugs to compensate for the lack of thyroid and other gland hormones. If early diagnosis and appropriate treatment are performed, the long-term harmful effects of this disease can be prevented and the quality of life can be improved.
There have been significant advances in the treatment of Sjögren's syndrome, including the use of immunosuppressive drugs, interventional drugs for symptom management, and the development of novel therapies. Although there is still no complete cure for this disease, recent advances have made it possible to improve symptoms and reduce the harmful effects of the disease.
Risk factors that may increase Sjogren's syndrome include gender, age, family history, environmental factors, other diseases, and more. Understanding these factors and taking preventive measures such as maintaining good health and controlling other diseases can help reduce the risk of developing Sjögren's syndrome.
Finally, early diagnosis, appropriate treatment, and regular care by specialist doctors can help manage and improve the quality of life of people with Sjogren's syndrome.