Introduction: Alzheimer’s disease is a neurodegenerative disease which imposes a heavy cost on the health system of different countries of the world. One of the pathological factors associated with Alzheimer's disease is neurofibrillary tangle that consists of accumulations of abnormally phosphorylated tau within the perikaryal cytoplasm of certain neurons. Alzheimer's disease is an undertreated disease. Currently, there are only two classes of approved drugs to treat AD, including inhibitors to cholinesterase enzyme and antagonists to N-methyl d-aspartate (NMDA), which are effective only in treating the symptoms of AD, but do not cure or prevent the disease.
Methods: The technique used in this research is molecular docking.The molecular docking approach is utilized to predict the tentative binding parameters of ligand-receptor complex. The main objective of molecular docking is to attain ligand-receptor complex with optimized conformation and with the intention of possessing less binding free energy.Bioethics importance in Bioinformatics and also having the advantage of low cost have made docking an increasingly important tool in pharmaceutical research.
Results: Inhibiting the excessive phosphorylation of Tau protein with the assistance of plant molecules which result in fewer side effects also prevents tau hyperphosphorylation and consequently Alzheimer's disease. In this research the docking of these plant molecules with tau protein will be examined utilizing The Molecular docking approach.
Conclusion: Inhibition of the binding site of phosphorus to tau protein for the purpose of preventing excessive phosphorylation will be followed
Keywords: Alzheimer, tau protein, Molecular docking