• The role of Faecalibacterium prasnitzii in gestational diabetes mellitus
  • Hanieh Safarzadeh,1 Siamak Heidarzadeh,2,*
    1. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zan-jan, Iran; haniehsafarzadeh1@gmail.com
    2. Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zan-jan, Iran; haniehsafarzadeh1@gmail.com


  • Introduction: In recent years, the incidence of metabolic disorders has exponentially increased worldwide mainly due to the misfunctioning of chemical reactions. Gestational diabetes mellites (GDM) occurred during pregnancy when placenta prevent absorption of sufficient insulin in mother’s body. Although this disorder usually disappears after delivery, it could raise the probability of developing complications in the future. In this review, we focus primarily on some causes and effects of GDM in pregnant women and then Faecalibacterium prasnitzii, the most abundant butyrate-producing bacterium in gut, which have been using as a prominent biomarker in health and disease and also potential anti-inflammatory treatment owing to production of active molecules
  • Methods: A PubMed search was conducted using the terms "Faecalibacterium prasnitzii", " Gestational diabetes mellitus," and "Microbiota". Only English articles published within the last five years were included
  • Results: Consumption of certain species of probiotics could effectively be beneficial for pregnant women and provide long-lasting benefits of health for them by reducing antioxidant and anti-inflammatory compounds released by harmful bacterial genera which are augmented and/or implemented in gut after challenging with GDM during pregnancy
  • Conclusion: Carrying out some mandatory clinical trials experiments are necessary to afford enough evidence to use this bacterium as a supplementary probiotic throughout pregnancy period
  • Keywords: Gut microbiota; Faecalibacterium prasnitzii; Gestational diabetes mellites