مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Probiotic Bacteria: A Promising Approach for Enhancing Wound Healing and Combating Biofilm Infections
Probiotic Bacteria: A Promising Approach for Enhancing Wound Healing and Combating Biofilm Infections
Narjes Mohammadi Bandari,1Mohammad Abootaleb,2,*
1. Agricultural Biotechnology Research Institute of Iran-North Branch (ABRII), Raika Gene Pharmed Technology Unit (company), Rasht, Gilan Province, Iran 2. Agricultural Biotechnology Research Institute of Iran-North Branch (ABRII), Raika Gene Pharmed Technology Unit (company), Rasht, Gilan Province, Iran
Introduction: Wound healing is a complex biological process that can be significantly hindered by the presence of biofilm-forming bacteria, leading to chronic infections and delayed recovery. Probiotic bacteria, known for their beneficial effects on human health, have emerged as a promising therapeutic strategy for enhancing wound healing and combating biofilm infections.
Methods: This review article explores the mechanisms by which probiotics can modulate the wound healing process, including their roles in promoting angiogenesis, collagen synthesis, and immune response modulation. We discuss the ability of specific probiotic strains to inhibit biofilm formation through competitive exclusion, production of antimicrobial substances, and modulation of host immune responses.
Results: Recent clinical studies demonstrate the efficacy of probiotics in improving wound healing outcomes and reducing infection rates in various patient populations. The findings indicate that probiotics can serve as adjunctive therapies in wound care, addressing challenges such as strain selection, delivery methods, and regulatory considerations.
Conclusion: This review aims to provide a comprehensive overview of the current state of research on probiotic bacteria in wound healing and biofilm infection management, emphasizing their potential to revolutionize treatment approaches in biomedicine. Given the numerous benefits of probiotics, further research is essential to better understand their mechanisms of action and optimize their use in wound and infection treatment.