Seyedeh Aida Hosseini,1Mohadesch Amini Musa Abadi,2Yalda Boozarjomehri,3Saman Hakimian,4,*
1. Undergraduate student of Microbiology Naghsh-e Jahan Non-Profit Institute 2. Undergraduate student of Microbiology Naghsh-e Jahan Non-Profit Institute 3. Undergraduate student of Microbiology Naghsh-e Jahan Non-Profit Institute 4. M.sc student of Pathogenic Microbes Islamic Azad University Central Tehran Branch Master
Introduction: Cystic fibrosis or cystic fibrosis (CF) is an autosomal recessive genetic disease characterized by a chronic course characterized by pancreatic exocrine insufficiency, chronic lung diseases, and increased concentrations of chlorine and sodium in sweat.
This monogenic disease is the most common life-shortening disease. This article focuses on knowing and dealing with the causes and symptoms of the disease, type of diagnosis, treatment and health maintenance. It also contains guidance that is important and suitable for all people with CF regardless of age and eligibility for this disease.
Methods: CF is an autosomal recessive genetic disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is possible that they help to absorb sodium ions (Na+). As a result, the mucus and secretions of the organs such as the lungs, pancreas, liver, intestines and reproductive system become dehydrated and thickened, and they are also thicker and stickier than usual, which creates a suitable environment for microbial growth and blocks them and receives It makes it difficult for nutrients to pass through the digestive system, thus causing damage. CF causes several chronic complications in the pancreas, lungs and other body organs such as thick mucus, bacterial infection and inflammation, gradual decrease in lung function and finally, death.
Results: Recent clinical evidence suggests that to better understand and slow CF disease progression, it is important to consider not only specific pathogens, but also the role of the entire airway microbial communities or airway microbiota, including their interactions and functions.
Conclusion: CF causes several chronic complications in the pancreas, lungs and other body organs such as thick mucus, bacterial infection and inflammation, gradual decrease in lung function and finally, death. In addition, the amount of salt in sweat gland secretions also increases and in in fact, the salt needed by the body is excreted through sweat. Although CF has been observed in all races, it is predominantly a disease of Northern European populations.
Keywords: digestive system,lung,mucus,genetic and Cystic fibrosis