مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Assessment of the Relationship Between CD44 Expression and Gleason Grade in Prostate Adenocarcinoma and Benign Prostatic Hyperplasia: A Cross-Sectional Study
Assessment of the Relationship Between CD44 Expression and Gleason Grade in Prostate Adenocarcinoma and Benign Prostatic Hyperplasia: A Cross-Sectional Study
Joben Kianparsa,1Masood Soltanipur,2Mohammadreza Jalali Nadoushan,3,*Amirmahdi Taromiha,4
1. Student Research Committee, School of Medicine, Shahed University, Tehran, Iran 2. Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran 3. Department of Pathology, Faculty of Medicine, Shahed University, Tehran, Iran 4. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Introduction: Prostate adenocarcinoma (PAC) ranks as the second most common cancer among men. The cluster of differentiation 44 (CD44) acts as a suppressor gene for metastatic tumors in PAC. This research aimed to examine the expression levels of CD44 in PAC in comparison to benign prostatic hyperplasia (BPH).
Methods: In this cross-sectional study, we analyzed CD44 expression in tissue samples from PAC and BPH using Hematoxylin & Eosin staining and immunohistochemistry techniques. We assessed the Gleason scores and grades, along with the percentage of CD44 expression in the specimens. Data analysis was conducted using IBM SPSS version 23.0 software.
Results: The study included 80 PAC samples and 83 BPH samples. The average CD44 expression in PAC samples was significantly lower than that in BPH samples (p < 0.001). A significant relationship was observed between CD44 expression and both the total Gleason scores and Gleason grade groups in PAC (p < 0.001). A moderate to strong significant negative correlation was identified between CD44 expression and total Gleason scores (r: -0.743, p < 0.001) as well as Gleason grade groups (r: -0.732, p < 0.001). Ordinal logistic regression indicated that CD44 expression negatively correlates with total Gleason scores (OR = 0.884, p < 0.001) and Gleason grade groups (OR = 0.884, p < 0.001).
Conclusion: This study underscores the potential of CD44 expression as a biomarker for diagnosing PAC, revealing significantly reduced levels of CD44 in PAC compared to BPH. The lower expression of CD44 is associated with higher Gleason scores and grades, indicating its involvement in disease progression and its implications for patient management strategies.