• Investigating the effect of pomegranate tallow hydroalcoholic extract on weight control and blood glucose level and liver enzymes of lab mice diabetic with streptozotocin
  • farahnaz mohammadi Tazeh Abadi,1 mitra ebrahimi,2 masoud fereidoni,3,*


  • Introduction: Examining the pharmacological properties of pomegranate oil and its active ingredients is important considering the clinical and health applications it can have in humans. Diabetes is a chronic disease that is characterized by a decrease in insulin secretion due to dysfunction of beta cells in the pancreas or an increase in insulin resistance. The tendency to treat diabetes with herbal medicines that have less side effects than chemical medicines is expanding day by day. This study was conducted with the aim of investigating the effect of pomegranate tallow hydroalcoholic extract on weight changes, blood glucose levels and liver enzymes in diabetic mice with streptozotocin administration.
  • Methods: 40 small male laboratory mice were divided into 5 groups with 8 repetitions and were kept in animal rooms with free access to water and food. They were divided per kilogram of pomegranate tallow hydroalcoholic extract. To induce diabetes, peritoneal administration of streptozotocin at the rate of 90 mg/kg was used, then the blood sugar levels of the rats were checked by a glucometer on a fasting basis.
  • Results: From day 10 to 15, the extract significantly and dose-dependently, with the best performance for the dose of 250 mg/kg, slowed down the weight loss process, p<0.001. In the study of fasting glucose in blood serum, the same performance for the extract in reducing blood glucose concentration p<0.001 The hydroalcoholic extract of pomegranate tallow in diabetic rats caused a significant decrease in AST enzyme compared to the diabetic control group in a dose-dependent manner, p<0.05, but only doses of 100 and 250 mg/kg hydroalcoholic extract of pomegranate tallow could significantly decrease the enzyme ALT compared to the control group. become diabetic, p<0.001.
  • Conclusion: The results of this research showed that the hydroalcoholic extract of pomegranate tallow, in addition to reducing blood sugar and controlling diabetes, regulates the activity of liver enzymes, it seems that one of the mechanisms of the hypoglycemic effect of pomegranate tallow extract is the increase of insulin secretion from pancreatic beta cells. which needs to be examined more closely.
  • Keywords: Pomegranate tallow, blood glucose, AST, ALT, streptozotocin