مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Exploring the relationship between circadian rhythm regulators and brain aging
Exploring the relationship between circadian rhythm regulators and brain aging
Faezeh Rezaei,1,*
1. Neurophysiology Research Center, Shahed University, Tehran, Iran
Introduction: Introduction: The interplay between chronobiology and neuroscience has garnered significant interest in recent years, particularly regarding the impact of molecules that regulate circadian rhythms on brain aging. The present review investigates the relationship between circadian rhythm regulators and the biological processes that contribute to age-related neurodegeneration. We examine how the disruption of circadian rhythms influences the expression and up/downregulation of specific molecules and how these variations correlate with cognitive decline, synaptic plasticity alterations, and the accumulation of neurotoxic proteins.
Methods: Methods: Through a comprehensive literature review and analysis of empirical studies in major databases using several set of keywords, we elucidated the potential relationship between circadian rhythm regulator molecules, neuroinflammatory pathways and oxidative stress responses in the aging brain.
Results: Results: Based on the observations we gathered from most recent studies, Brain and Muscle Arnt-Like 1 (BMAL1) transcription factor which plays an important role in generation of circadian rhythms, has also been associated with the process of memory formation and aging. BMAL1, and its binding-partner CLOCK, were found to correlate negatively with age. Oxidative stress and inflammation pathways appear to play mediators in this interplay.
Conclusion: Our findings suggest that maintaining circadian rhythm stability may be crucial for promoting neuronal resilience and cognitive health in aging populations. This research underscores the significance of circadian rhythm regulators as potential biomarkers and therapeutic targets for mitigating the effects of brain aging, paving the way for novel interventions that align with the body's natural rhythms.