• The intestinal dysbiosis and stroke
  • Reza Bayat,1 Shokouh Rahmati pour,2 Zahra Rezvani,3,*
    1. Department of cell and molecular biology, Faculty of chemistry, University of Kashan, Kashan, Iran.
    2. Department of cell and molecular biology, Faculty of chemistry, University of Kashan, Kashan, Iran.
    3. Department of cell and molecular biology, Faculty of chemistry, University of Kashan, Kashan, Iran


  • Introduction: Stroke is the second leading cause of death and the third leading cause of disability in the world, which imposes a huge cost on the health of the society. Strokes are divided into two types, ischemic and hemorrhagic, which are mostly ischemic and are caused by blockage of arteries and lack of blood and oxygen to a part of the brain. Improper diet and genetic factors are effective in stroke. Recent research shows that the gut microbiome has a two-way connection with the brain, which is called the gut-brain axis (GBA). The gut microbiome and its derived metabolites regulate GBA signaling and play an important role in brain functions. Also, its metabolites, such as butyrate, acetate and propionate, help control inflammation after a stroke by regulating the immune system. The human digestive system contains millions of bacteria that maintain the integrity of the intestinal epithelial barrier .Many researches have shown that dysbiosis in the intestinal microbiome causes destructive signals on the gut- brain axis and also increases the possibility of contracting other inflammatory diseases. Intestinal dysbiosis is related to two-sided stroke, which can be a premonition before the stroke, and after it, it can be a symptom of a stroke, which also brings digestive problems
  • Methods: In this study, the effect and two-way communication between gut and brain microbiomes were studied, which were extracted and used from reliable information sources such as Google Scholar, PubMed and Science Direct
  • Results: The results show that disorganization in the gut microbiome by various factors increases the risk of stroke through misplaced signals of the gut-brain axis and the entry of toxic bacteria into the bloodstream that causes the production of inflammatory substances. Also, after a stroke, the patient is faced with intestinal dysbiosis, followed by an increase in the secretion of inflammatory cytokines and the loss of integrity of the intestinal barrier, which causes digestive problems such as bloating and constipation. Research has shown that the use of probiotic supplements regulates the gut microbiome and reduces stroke symptoms
  • Conclusion: Due to the importance of maintaining the intestinal microbiome, it is possible to prevent dysbiosis of the intestinal microbiome by reducing the inflammation caused by the immune system and reduce the risk of neurological diseases, including stroke
  • Keywords: stroke, probiotics, gut microbiome, gut-brain axis