• Impact of SNPs in Implantation-Related Genes on Recurrent Implantation Failure (RIF) and Their Role in Reproductive Health
  • Paria sadat Agha seyed mirzaei,1 Dr.masoud sheidai,2,*
    1. Department of Cell and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran.
    2. Department of Cell and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran.


  • Introduction: Recurrent implantation failure (RIF) presents a challenge in the field of reproductive medicine and impacts about 15% of women who undergo in vitro fertilization (IVF). One area of growing interest focuses on exploring the influence of nucleotide polymorphisms (SNPs) within genes associated with implantation processes that affect angiogenesis dynamics, endometrial receptivity levels and interactions between the embryo and the maternal environment. This study seeks to explore how these genetic variations impact women fertility and their role, in recurrent implantation failure through an examination of previous studies and real world results.
  • Methods: Information was analyzed through seven articles that examined the association between SNPs in genes related to angiogenesis (FLT1, VEGFA, KDR and FGF2) and recurrent implantation failure. Research encompassed populations such as Korean and Polish cohorts. Genetic variations were identified through methods, like PCR RFLP with comparisons made between the allele frequencies of women and control groups. They also used haplotype analyses methods and tests such as logistic regression and chi squared.
  • Results: The variation in VEGFA gene (rs699947) in particular showed a heightened association with RIF risk. women with AA genotype were notably more susceptible to implantation failure (OR=2·34, p=0·023). the genetic variation, in KDR gene (rs2071559) was discovered to raise infertility and RIF risks among women undergoing assisted reproductive procedures. An analysis of gene interactions discovered a combined impact involving KDR (rs2071559) and VEGFA (rs699947). In contrast there were no connections found between the FLT and FGF gene variations and RIF. These results highlight the significance of variations within the angiogenesis pathway, in influencing recurrent implantation failure.
  • Conclusion: The association of recurrent implantation failure with SNPs in genes associated with angiogenesis particularly, VEGFA and KDR is very important. These SNPs associated with RIF can act as a genetic marker in the diagnosis of the condition. Although FLT1 and FGF2 SNPs were not significantly associated, the attention on compound polymorphisms indicates the need for more studies on their mechanisms Many of these revelations are essential for further improving the results of the assisted reproductive technology by genetic targeting of the infertility treatment and The collective effect is important in revealing the complex interplay between genetics and clinical factors in the context of RIF.
  • Keywords: SNPs, Recurrent Implantation Failure (RIF), VEGFA, KDR, Angiogenesis