مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Viral Metagenomics in Stray and Domestic Dogs; A Systematic Review
Viral Metagenomics in Stray and Domestic Dogs; A Systematic Review
amin afsahi,1,*zahra aeini,2kimia Amouyan,3
1. Department of Pathobiology, Faculty of Veterinary Specialized Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran 2. Viral Metagenomics in Stray and Domestic Dogs; A Systematic Review 3. Department of Pathobiology, Faculty of Veterinary Specialized Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
Introduction: Many human viral infections have a common origin between humans and animals, and if a virus can adapt and replicate in its new human host, human-to-human transmission may occur, leading to an epidemic such as the 2009 H1N1 influenza pandemic. to be Therefore, the prediction of emerging zoonotic infections will be an important challenge for public health officials in the coming decades. Viral metagenomics is a powerful tool for exploring new viruses in different human and animal tissue and feces samples and responding to this challenge.
Methods: We systematically reviewed studies that used this tool to examine the feces of stray and domestic dogs. By searching PubMed, Google Scholar, and Web of Science databases using the keywords “viral metagenomics,” “dog,” “stray dog,” “domestic dog,” “intestinal virome,” and “faecal virome,” 517 We identified the study and finally after screening, 33 articles were analyzed.
Results: Studies have shown a high diversity of viruses of Astroviridae, Coronaviridae, Circoviridae, Picornaviridae, Caliciviridae, Herpesviridae, Parvoviridae, Microviridae, Siphoviridae, Ackermannviridae families in the fecal virome of healthy dogs. Also, the results showed that stray dogs may have new viral species of Astroviridae, strains of Coronaviridae that have a common potential between humans and animals, and the virus that causes hepatitis E. Due to the lack of vaccination and contact with infected animals, stray dogs are mostly infected with enteric viruses such as parvovirus and canine adenovirus. and due to the interaction with different ecosystems, the diversity of environmental phages and viruses of the Microviridae and Siphoviridae families was also higher in stray dogs. The results also showed the different virome composition of dogs with diarrhea compared to healthy dogs, and known intestinal pathogens such as parvovirus and coronavirus were present in both healthy dogs and dogs with diarrhea, and astrovirus in dogs with Acute diarrhea was significantly higher.
Conclusion: This systematic review provides an overview of the current state of knowledge on viral metagenomics in domestic and stray dogs and highlights the importance of ongoing research and surveillance to prevent viral disease transmission.