• Investigating the Influencing Factors on the Process of Assisted Reproductive Treatments (ARTs)
  • Mohammad Hossein Madahali,1,*
    1. Department of Anatomical sciences and cell biology ,Mashhad University of Medical Sciences ,Mashhad ,Iran


  • Introduction: Assisted reproductive treatments (ARTs) are medical procedures used to help individuals and couples have a child. Success of these treatments is influenced by factors like age, hormonal imbalances, sperm quality, lifestyle, previous pregnancies, medical conditions, type of ART, quality of the medical team, number of embryos transferred, and genetic factors. Common ARTs include In Vitro Fertilization (IVF), Intrauterine Insemination (IUI), Ovulation Induction (OI), Intracytoplasmic Sperm Injection (ICSI), Frozen Embryo Transfer (FET), Donor Egg or Sperm, and Surrogacy. These treatments are commonly used to help overcome infertility and achieve pregnancy.
  • Methods: The present study was conducted by reviewing related articles in Web of Science, Scopus, and PubMed databases.
  • Results: The most common assisted reproductive treatments include In Vitro Fertilization (IVF), Intrauterine Insemination (IUI), Ovulation Induction (OI), Intracytoplasmic Sperm Injection (ICSI), Frozen Embryo Transfer (FET), Donor Egg or Sperm, and Surrogacy. These treatments help individuals and couples overcome infertility and achieve pregnancy. Risks associated with assisted reproductive treatments include increased risk of adverse perinatal outcomes, birth defects, and potential long-term health risks for children conceived through these techniques. Short-term health risks include adverse perinatal outcomes, complications of multiple pregnancies, uncertainty in outcomes, and epigenetic alterations that could lead to later health issues. Long-term health risks are not well studied, but concerns exist about the effects of endocrine manipulation on hormone-sensitive conditions in female patients. Additional research is needed to fully understand the long-term health outcomes of assisted reproductive treatments, especially in terms of potential risks for females undergoing these procedures.
  • Conclusion: The most common complications of assisted reproductive treatments (ARTs) include thromboembolic disease, pregnancy complications, genital cancers, and fetal and neonatal complications. These risks underscore the importance of understanding and managing the risks associated with ART procedures for the safety of both the mother and child. The most common obstetric complications associated with ARTs include preeclampsia, gestational diabetes, placenta accreta spectrum, multiple pregnancies, and advanced maternal age. Careful monitoring and management during pregnancy following ART procedures are essential to ensure the well-being of both the mother and child. Symptoms of abnormal placentation in assisted reproductive treatments can include vaginal bleeding, pain, preterm labor, placenta previa, and fetal distress. Early detection and management of abnormal placentation are crucial for ensuring the well-being of both the mother and baby. Risks of abnormal placentation in ARTs include placenta previa, placenta accreta, and vasa previa, which can cause significant maternal and perinatal morbidity and mortality. Risk factors for abnormal placentation include prior cesarean delivery, smoking, multifetal gestation, and maternal age. Advances in ultrasound have improved prenatal diagnosis and management of abnormal placentation for better outcomes for mother and baby.
  • Keywords: Assisted Reproductive Treatments (ARTs) - risk factors - IVF- infertility