• Investigating the effect of hyaluronic acid on the antimicrobial responses of nanocomposite drugs
  • Zahra Bayat Sarmadi,1,*
    1. Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran


  • Introduction: The resistance of microorganisms to antimicrobial agents is a very important global health challenge that leads to the development of innovative materials to fight infections. Hyaluronic acid is a polysaccharide known for its biocompatibility and moisture retention properties. This biological compound has been used as a promising component in various fields including treatment, for example, its importance in antimicrobial nanocomposites has been pointed out in this research. This review article examines the potential effects of hyaluronic acid on the efficacy and performance of antimicrobial compounds.
  • Methods: To collect the data of this research, studies related to the synergism effect of hyaluronic acid in various nanocomposites, including silver nanoparticles, zinc oxide, and systems based on chitosan and some other nanopolymers, were conducted. In this research, synthesis methods, material optimization and antimicrobial methods and tests were investigated.
  • Results: Observations show that the use of hyaluronic acid in the pharmaceutical composition increases the effectiveness of the treatment by helping the antimicrobial properties of nanocomposites due to its unique interactions with bacterial membranes and improving drug delivery. Investigations showed that nanocomposites combined with hyaluronic acid show better antibacterial effects that significantly reduce microbial resistance compared to older pharmaceutical compounds.
  • Conclusion: Hyaluronic acid with a significant effect on the antimicrobial effect of nanocomposites helps to provide a valuable strategy for the development of the next generation of treatment. Further studies to optimize the concentration of hyaluronic acid, investigate the long-term effects of this compound and obtain new solutions for clinical applications in wound healing and infection control will pave the way for these new treatments.
  • Keywords: Nano composite, Hyaluronic acid, Anti Bacterial treatment, Improve treatment