• Anti-helicobacter pylori peptides: promises and challenges
  • Golnaz Najaflou,1,* Saeid Latifinavid,2 Esmat Abdi,3 Alireza Panahi,4
    1. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 5619911367, Iran
    2. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 5619911367, Iran
    3. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 5619911367, Iran
    4. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 5619911367, Iran


  • Introduction: Anti-Helicobacter pylori (H. pylori) peptides have emerged as a novel approach for treating infections caused by this bacterium. H. pylori is the primary cause of gastric ulcers, duodenal ulcers, and certain gastric cancers. Traditional treatments include antibiotics and proton pump inhibitors, but rising antibiotic resistance has increased the need for new solutions. The first antimicrobial peptide specifically targeting H. pylori, the human cathelicidin LL-37, was identified in 1995 by Dr. Rolf David and colleagues at Lund University, Sweden. LL-37 plays a key role in combating antibiotic-resistant infections. Antimicrobial peptides (AMPs) have gained attention due to their strong antibacterial activity, lower drug resistance, anti-inflammatory properties, and specific targeting, with some peptides binding directly to H. pylori and eliminating the bacteria without harming the stomach’s natural flora
  • Methods: To this end, MEDLINE, EMBASE, LILACS, AIM, and IndMed databases were searched for relevant articles since 1995
  • Results: Anti-H. pylori peptides offer more effective treatment options, but realizing their full potential requires addressing these challenges. Continued advancements in these areas could lead to the development of new, more efficient therapies
  • Conclusion: Using antimicrobial peptides represents a promising, innovative approach to treating H. pylori infections. Overcoming current challenges will require extensive research to fully harness the potential of these compounds, paving the way for safe and effective treatments
  • Keywords: anti-inflammatory properties, gastric cancers, antibiotic.