مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
The Interconnection Between Type 2 Diabetes and Colon Cancer: Mechanisms, Risks, and Management Strategies
The Interconnection Between Type 2 Diabetes and Colon Cancer: Mechanisms, Risks, and Management Strategies
Amir Hossein Ghorbani Pour Mohammadi,1,*Saba Rahimi,2
1. Department of quantum and converging science Branch, Tehran Islamic Azad University, Tehran, Iran 2. Department of quantum and converging science Branch, Tehran Islamic Azad University, Tehran, Iran
Introduction: Colon cancer and type 2 diabetes are both widespread chronic conditions that significantly affect health. Recent research indicates a complex interplay between type 2 diabetes and colon cancer, with diabetes potentially impacting the risk and progression of colon cancer. This review seeks to investigate the effects of type 2 diabetes on colon cancer, emphasizing the biological mechanisms, epidemiological data, and implications for treatment and management. Understanding this relationship is crucial for developing effective prevention and intervention strategies for individuals affected by both diseases.
Methods: To assess the impact of type 2 diabetes on colon cancer, we conducted a thorough review of the available literature. We searched databases such as PubMed, Scopus, and Web of Science for peer-reviewed articles published up to September 2024. The inclusion criteria were studies that examined the association between type 2 diabetes and colon cancer risk, progression, or management. We also reviewed studies investigating potential biological mechanisms, including insulin resistance, inflammation, and metabolic alterations.
Results: Increased Risk of Colon Cancer in Type 2 Diabetes
Epidemiological studies consistently demonstrate that individuals with type 2 diabetes have a higher risk of developing colon cancer compared to those without diabetes.
Biological Mechanisms Linking Type 2 Diabetes and Colon Cancer
Factors associated with type 2 diabetes, such as hyperinsulinemia, chronic inflammation, and metabolic syndrome, are implicated in promoting colon cancer development. Insulin resistance and elevated glucose levels contribute to a pro-cancerous environment by affecting cell proliferation and apoptosis.
Alterations in the gut microbiome linked to type 2 diabetes may affect the risk of developing colorectal cancer, presenting an opportunity for further investigation.
Implications for Colon Cancer Management
Strategies for managing diabetes, including specific antidiabetic medications and lifestyle changes, seem to impact outcomes in colon cancer. However, findings are inconsistent, indicating additional research is needed to clarify these relationships and develop effective recommendations.
Conclusion: Type 2 diabetes is associated with a heightened risk of colon cancer, with studies highlighting that metabolic and inflammatory processes are significant contributors to this connection. The relationship between these two conditions is complex and influenced by various biological and environmental factors. Effective control of type 2 diabetes may reduce the risk of colon cancer, but further research is necessary to improve treatment strategies and outcomes for individuals facing both health issues. Future research should concentrate on identifying the specific mechanisms that link diabetes and colon cancer, as well as developing integrated approaches to prevention and treatment.