مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Unveiling the Antibacterial Potential of Chrysin: A Naturally Occurring Flavonoid in Plants
Unveiling the Antibacterial Potential of Chrysin: A Naturally Occurring Flavonoid in Plants
Mansoureh Taghizadeh,1,*
1. Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: The exploration of natural compounds with antimicrobial properties has gained significant attention in the context of increasing antibiotic resistance. Chrysin, a naturally occurring flavonoid found in plants, has emerged as a promising candidate owing to its diverse biological activities. This review aimed to reveal the potential of chrysin as an antimicrobial agent and provide a comprehensive understanding of its properties and mechanisms of action.
Methods: A thorough literature search was conducted to identify relevant studies investigating the antimicrobial activity of chrysin. Various scientific databases including PubMed, Scopus, and Web of Science were searched using keywords related to chrysin, antimicrobial activity, and plant sources. Studies using in vitro and in vivo models to evaluate the antimicrobial effects of chrysin were included. The selected studies were critically reviewed and analyzed to extract key information regarding the antimicrobial potential and mechanism of action of chrysin.
Results: The reviewed studies consistently demonstrate the antimicrobial potential of chrysin against a broad spectrum of microorganisms. Chrysin exhibits inhibitory effects against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains. It also shows antifungal activity against various fungal species, and exhibits antiviral effects against certain viruses. The mechanism of action of chrysin involves multiple targets within microbial cells, making it difficult for microorganisms to develop resistance. Additionally, chrysin demonstrated synergistic effects when combined with conventional antimicrobial agents, suggesting its potential as an adjuvant therapy.
Conclusion: Chrysin, a natural flavonoid abundant in plants, possesses significant antimicrobial properties. Its broad-spectrum activity, coupled with its multiple mechanisms of action, make it a promising candidate for the development of novel antimicrobial agents. Further research is required to optimize chrysin extraction methods, evaluate their safety profiles, and explore their potential clinical applications. The discovery of chrysin as a natural antimicrobial compound opens avenues for the development of alternative strategies to combat microbial infections and address the global challenge of antibiotic resistance.