مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
Induced pluripotent stem cells: definition, production and their applications
Induced pluripotent stem cells: definition, production and their applications
Omid Reza Veysi,1Farzad Nezafati,2,*
1. 7th grade(Middle school), Professor Shamsipour institue, Kermanshah, Iran. 2. Department of Biology, Kermanshah branch, Islamic Azad University, Kermanshah, Iran.
Introduction: Induced pluripotent stem cells (IPSCs) are cells that originate from adult cells that have been reprogrammed into stem cells. Therefore, these cells can differentiate into other cells. The use of this technique was done for the first time by Shinya Yamanaka and his team, who were able to reprogram mature cells and produce induced pluripotent stem cells by using specific gene vectors.
Methods: For this study we used the keyword “IPS cells” and “Stem cells” in Google Scholar database. And we just accepted review articles to our research. Finally We divided the obtained data into three categories. These categories are: 1) definition, 2) production and 3) their applications.
Results: There are different methods to create induced pluripotent stem cells, which include somatic nucleus transfer, use of specific transcription factors, micro RNA and other methods. Each of these methods has advantages and disadvantages, for example, in the use of micro RNA, specific genes can be activated, but it can be said that the interaction of this micro RNA with other parts has not been well defined yet. Induced pluripotent stem cells have various uses according to their characteristics. including use in basic research (for example, one way to study embryonic stem cells is to use these types of cells), drug screening, toxicology, disease modeling, and cell therapy.
Conclusion: Despite numerous researches on induced pluripotent stem cells, they always face challenges that we hope to overcome with more study and research.