• Investigation of the impact of coagulation markers in predicting mortality for severe COVID-19 in hospitalized patients
  • Hamidreza Karbalaei-Musa,1 Mohammad Hossein Hajali,2 Babak Jahangirifard,3,*
    1. ‎Student Research Committee, AJA University of Medical Sciences, Tehran, Iran‎
    2. ‎Student Research Committee, AJA University of Medical Sciences, Tehran, Iran‎
    3. Department of Anesthesia and Intensive Care‎, School of Medicine‎, Aja University of Medical Sciences, Tehran, ‎Iran


  • Introduction: The COVID-19 pandemic has created significant challenges for global healthcare systems and there is a need to fully investigate the factors that affect patient outcomes, especially in severe cases requiring special care. Therefore, studying predictive factors of mortality in patients with severe cases of this disease is of particular importance and identifying these factors can be effective in the success rate of treatment for these patients.
  • Methods: A descriptive-analytical, cross-sectional, and retrospective study was conducted in the intensive care unit of a hospital in Tehran city from March 2022 to April 2023. laboratory data related to coagulation factors of 395 patients with severe COVID-19 were collected. Data analysis was performed using statistical tests.
  • Results: The evaluated coagulation factors included platelet level, PT, INR, ferritin, D-dimer, and fibrinogen. In deceased patients, platelet levels were lower, but there was no significant difference compared to recovered patients (p=0.587). Although this study showed higher levels of PT and INR in deceased patients, they did not have a significant difference compared to the living group (p=0.132, p=0.248) and ferritin and D-dimer levels were significantly higher in deceased patients (p=0.047, p=0.057, p=0.047).
  • Conclusion: The systemic status of patients, including the level of some inflammatory factors, affects the mortality rate of COVID-19. Appropriate interventions and preventive management strategies aimed at addressing these risk factors are essential for improving patient outcomes and can impact the quality of patient care in hospital settings.
  • Keywords: Covid-19, mortality, risk factors