• The impact of nanotechnology on drug delivery systems and advanced treatment results
  • Arezoo Nazari,1,* Mandana Zarei,2 Mohsen Mehrabi,3
    1. Department of Biological science and Technology,Faculty of Nano and Bio Science and Technology,Persian Gulf University,Bushehr 7516913817,Iran
    2. Department of Biological science and Technology,Faculty of Nano and Bio Science and Technology,Persian Gulf University,Bushehr 7516913817,Iran
    3. Physics Department, Persian Gulf University, Bushehr, Iran, P. O. Box: 7516913817


  • Introduction: Nanotechnology involves the manipulation of materials at the nanoscale, typically within the range of 1–100 nanometers. The unique physicochemical properties exhibited by nanomaterials, such as high surface area to volume ratio and quantum confinement effects, have attracted significant attention in the field of drug manufacturing. Nanotechnology offers several advantages, including improved drug solubility, enhanced stability, targeted drug delivery, and controlled release. These advancements have the potential to revolutionize the pharmaceutical industry and improve patient outcomes [1]. Nanotechnology in Drug Delivery: One of the key applications of nanotechnology in drug manufacturing is in the development of novel drug delivery systems. Nanoparticles, liposomes, and micelles are some examples of nanocarriers that can encapsulate drugs and deliver them to specific target sites in the body. These nanocarriers can enhance drug solubility, protect the drug from degradation, and enable controlled release, thereby improving drug efficacy and reducing side effects [2]. Improved Drug Solubility and Stability: Poor solubility is a major challenge in drug development. Nanotechnologyoffers various strategies to enhance drug solubility, including the use of nanoparticles and nanocrystals. These nanosized formulations increase the surface area available for dissolution and improve drug bioavailability. Furthermore, nanotechnology can improve the stability of drugs by protecting them from environmental factors, such as light and moisture, which can degrade their efficacy [3]. Targeted Drug Delivery: Nanotechnology enables targeted drug delivery, where drugs are delivered specifically to the site of action, minimizing systemic side effects. Surface functionalization of nanoparticles allows for specific targeting of diseased cells or tissues. Moreover, stimuli-responsive nanocarriers can release drugs in response to specific triggers, such as pH, temperature, or enzymes, further enhancing their targeting capabilities [4]. Controlled Drug Release: Nanotechnology enables precise control over drug release kinetics. By modifying the surface properties or incorporating stimuli-responsive components, nanocarriers can release drugs in a controlled manner. This controlled release profile ensures sustained therapeutic levels of the drug, reducing the frequency of dosing and improving patient compliance [5, 6]. Safety Considerations and Regulatory Aspects: While nanotechnology offers immense potential in drug manufacturing, it is essential to address safety concerns associated with nanomaterials. The potential toxicity of nanoparticles and their long-term effects on human health require a thorough evaluation. Regulatory bodies are actively working to establish guidelines for the safe use of nanomedicine and to ensure the quality, efficacy, and safety of nanotechnology-based drug products [6, 7]. Future Perspectives and Challenges: The utilization of nanotechnology in drug manufacturing is still in its early stages, and there are several challenges that need to be addressed. These include the scalability of manufacturing processes, cost-effectiveness, reproducibility, and long-term safety. However, with ongoing research and advancements, nanotechnology has the potential to revolutionize drug manufacturing and pave the way for personalized medicine [8, 9].
  • Methods: Studying and extracting articles from NCBA, Gigalib, and Scopus databases
  • Results: Nanotechnology in drug delivery has shown promising results in improving drug solubility, stability, targeted delivery, and controlled release. By utilizing nanocarriers such as nanoparticles, liposomes, and micelles, drugs can be encapsulated and delivered to specific target sites in the body, enhancing efficacy and reducing side effects. Additionally, nanotechnology allows for precise control over drug release kinetics, ensuring sustained therapeutic levels and improved patient compliance. While there are safety concerns and regulatory aspects to consider, ongoing research and development in nanomedicine hold the potential to revolutionize drug production and advance personalized medicine.
  • Conclusion: Nanotechnology has emerged as a powerful tool in drug manufacturing, offering numerous advantages in terms of drug solubility, stability, targeting, and release. The applications of nanotechnology in drug delivery systems have the potential to improve therapeutic outcomes and reduce side effects. However, further research and development, along with regulatory guidelines, are required to fully harness the potential of nanotechnology in the pharmaceutical industry. With continued advancements, nanotechnology is poised to transform the way drugs are manufactured, leading to more effective and personalized treatments.
  • Keywords: Nanomaterials, Nanotechnology, Drug, Therapy, Delivery system