مقالات پذیرفته شده در هشتمین کنگره بین المللی زیست پزشکی
A review of the role of the human microbiome in the pathogenesis of pain
A review of the role of the human microbiome in the pathogenesis of pain
Mahdiyeh Mirzalou,1,*Marziyeh Mirzalou,2
1. Department of Biological sciences and technologies, School of Medical Sciences., University of Azad marand Branch., marand, Iran 2. Department of Biological sciences and technologies, School of Medical Sciences., University of Azad marand Branch., marand, Iran
Introduction: The intestine has the most populous and diverse anaerobic and aerobic micro-photosystem. Living organisms in the human body are mainly composed of bacteria, however, yeasts, archaea, or parasites that live in a large area of the digestive tract often play a secondary role.
Methods: To identify studies aimed at the role of the human microbiome in the pathogenesis of pain, this systematic review was conducted in the databases of Science Direct, and PubMed Google Scholar, based on the keywords Microbiome, Pain, and Treatment. After reviewing the summary of the articles and checking the title, the irrelevant articles were removed. The full text of the articles was searched and the articles related to the subject were included in the study.
Results: According to the studies, the growing evidence related to the microbiome with stress, anxiety, depression, neurological diseases, and brain functions under the influence of microorganisms can cause pain intensification. gut microbiota covers pain and is a new and promising therapeutic approach for pain management.
Conclusion: Recent studies show that the human microbiome may be an essential component of the pathogenesis of various types of pain. Also, further molecular studies can create new targets for painkiller treatment, significantly improving many patients' quality of life.